سعر اميجران ادكو amigraine adco‏ 30 قرص للصداع النصفي 2026

Amigraine tablets (caffeine + metamizole (dipyrone) + ergotamine), pack of 30 (ADCO); antimigraine.

• Ergotamine/caffeine: vasoconstrictive ischaemic complications, nausea, vomiting, paraesthesia, numbness, weakness, vertigo, tachycardia or bradycardia.General active-ingredient information · DailyMed (NLM)

• Ergotamine: contraindicated with potent CYP3A4 inhibitors (protease inhibitors, macrolides such as erythromycin/clarithromycin, azole antifungals); in pregnancy; peripheral vascular disease, coronary heart disease, uncontrolled hypertension, impaired hepatic or renal function, sepsis; hypersensitivity.General active-ingredient information · DailyMed (NLM)

• Boxed warning (ergotamine): serious and/or life-threatening peripheral ischaemia (cerebral and/or extremity ischaemia) has occurred when ergotamine was co-administered with potent CYP3A4 inhibitors.General active-ingredient information · DailyMed (NLM)
• Ergotamine: retroperitoneal and/or pleuropulmonary fibrosis and rare fibrotic thickening of heart valves reported with long-term continuous use; not for chronic daily administration; stay within the recommended dosage (ergotism).General active-ingredient information · DailyMed (NLM)
• Metamizole: agranulocytosis (sudden severe fall in granulocytes, potentially fatal infections) can occur at any time during or shortly after treatment, independent of dose; patients must stop the medicine and seek immediate medical attention if fever, chills, sore throat or painful mucosal sores develop.General active-ingredient information · European Medicines Agency (EMA)

• Potent CYP3A4 inhibitors (ritonavir and other protease inhibitors, erythromycin, clarithromycin, ketoconazole, itraconazole)Raise ergotamine levels causing vasospasm and peripheral ischaemia; contraindicated.DailyMed (NLM)
• Sumatriptan and other 5-HT1 agonists, other vasoconstrictorsAdditive vasospastic effects.DailyMed (NLM)

• Ergotamine-containing products are contraindicated in pregnancy (oxytocic properties; US Cafergot label).General active-ingredient information · DailyMed (NLM)
• Ergotamine is excreted in breast milk and may cause vomiting, diarrhoea, weak pulse and unstable blood pressure in nursing infants; caution.General active-ingredient information · DailyMed (NLM)

• Caffeine: Most effects are attributed to antagonism of adenosine A1 and A2A receptors (UK caffeine citrate SmPC).
• Metamizole (dipyrone):
• Ergotamine: Alpha-adrenergic blocking agent with direct stimulating (vasoconstrictive) effect on peripheral and cranial vascular smooth muscle; serotonin antagonism (US Cafergot label).