سعر اواديست ميجرين 20 قرص 2023

Combination antimigraine tablets containing paracetamol 300 mg, ergotamine 1 mg and caffeine 100 mg, pack of 20 film-coated tablets (2 strips) (HP Pharma, Egypt).

• Abortive or preventive therapy for vascular headache, e.g. migraine and migraine variants (ergotamine + caffeine components)Population: AdultsDailyMed (U.S. National Library of Medicine)
• Headache including migraine (paracetamol component)Population: Adults and children 10 years and older (single-ingredient paracetamol 500 mg)electronic medicines compendium (eMC)

• Ergotamine/caffeine components: vasoconstrictive complications (ischaemia, cyanosis, absence of pulse, numbness), nausea, vomiting, paraesthesias, tachycardia or bradycardia, and rarely fibrotic changes.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ergotamine component: co-administration with potent CYP3A4 inhibitors (e.g. ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Ergotamine component: pregnancy; peripheral vascular disease; coronary heart disease; hypertension; impaired hepatic or renal function; sepsis; hypersensitivity to any component.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Paracetamol component: hypersensitivity to paracetamol; do not take with any other paracetamol-containing medicine.General active-ingredient information · electronic medicines compendium (eMC)

• Boxed warning (ergotamine): serious and/or life-threatening peripheral ischaemia (cerebral and extremity ischaemia) has been associated with co-administration of ergotamine with potent CYP3A4 inhibitors.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Ergotamine component: not for chronic daily use; prolonged use may cause fibrotic changes (pleural, retroperitoneal) and ergotism; do not exceed the recommended dose.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Paracetamol component: do not exceed the stated dose; care in severe renal or severe hepatic impairment; overdose hazards are greater in non-cirrhotic alcoholic liver disease; overdose can cause delayed serious liver damage even if the patient feels well.General active-ingredient information · electronic medicines compendium (eMC)

• Potent CYP3A4 inhibitors (protease inhibitors, macrolide antibiotics, azole antifungals)MajorContraindicated: risk of vasospasm leading to cerebral or peripheral ischaemia.DailyMed (U.S. National Library of Medicine)
• Vasoconstrictors and sympathomimetics (including in local anaesthetics)Ergotamine may add to the pressor effect; avoid combination.DailyMed (U.S. National Library of Medicine)
• Beta-blockers (propranolol), nicotineMay enhance ergotamine-induced vasoconstriction.DailyMed (U.S. National Library of Medicine)

• Ergotamine component: contraindicated in pregnancy (oxytocic properties).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Paracetamol component: a large amount of pregnancy data shows neither malformative nor feto/neonatal toxicity; if clinically needed it can be used at the lowest effective dose for the shortest time.General active-ingredient information · electronic medicines compendium (eMC)
• Ergotamine component: excreted in breast milk and may cause vomiting, diarrhoea, weak pulse and unstable blood pressure in nursing infants; not to be used by nursing mothers per the US label.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

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