سعر املوفيران بلس 10/2.5/10مجم 30 قرص 2024

Fixed-dose triple combination film-coated tablet (Eva Pharma) containing perindopril arginine 10 mg, indapamide 2.5 mg and amlodipine 10 mg; 30 tablets.

• Substitution therapy for treatment of essential hypertension in patients already controlled with perindopril/indapamide fixed-dose combination and amlodipine taken concurrently at the same dose level.Population: AdultsSAHPRA PI/PIL repository (South African Health Products Regulatory Authority)

• Common: dizziness, headache, paraesthesia, vertigo, somnolence, visual disturbance, tinnitus, palpitations, flushing, hypotension, cough, dyspnoea, gastrointestinal disorders, rash, muscle cramps, oedema, fatigue, hypokalaemia.International label, same formulation · SAHPRA PI/PIL repository (South African Health Products Regulatory Authority)

• Hypersensitivity to perindopril or other ACE inhibitors, indapamide or other sulfonamides, amlodipine or other dihydropyridines; history of angioedema.International label, same formulation · SAHPRA PI/PIL repository (South African Health Products Regulatory Authority)
• Pregnancy and lactation; lithium therapy; dialysis; hypokalaemia; untreated decompensated heart failure; severe hypotension, shock, left ventricular outflow obstruction, haemodynamically unstable heart failure after acute MI; aliskiren in diabetes or renal impairment (GFR below 60); sacubitril/valsartan (not within 36 hours).International label, same formulation · SAHPRA PI/PIL repository (South African Health Products Regulatory Authority)

• Risk of angioedema, hypotension, renal impairment, electrolyte disturbances (hypokalaemia, hyponatraemia) and hepatic encephalopathy with thiazide-related diuretics in liver disease; monitor electrolytes.International label, same formulation · SAHPRA PI/PIL repository (South African Health Products Regulatory Authority)

• LithiumContraindicated: concomitant administration may lead to toxic blood lithium concentrations.SAHPRA PI/PIL repository (South African Health Products Regulatory Authority)
• Potassium-sparing diuretics, potassium supplementsRisk of hyperkalaemia; generally not recommended.SAHPRA PI/PIL repository (South African Health Products Regulatory Authority)

• Contraindicated during pregnancy.International label, same formulation · SAHPRA PI/PIL repository (South African Health Products Regulatory Authority)
• Contraindicated during lactation.International label, same formulation · SAHPRA PI/PIL repository (South African Health Products Regulatory Authority)

• Perindopril (as perindopril arginine): Inhibits angiotensin-converting enzyme, reducing conversion of angiotensin I to the vasoconstrictor angiotensin II and the degradation of bradykinin.
• Indapamide: Inhibits sodium reabsorption in the cortical diluting segment, increasing urinary sodium and chloride excretion.
• Amlodipine: Inhibits transmembrane calcium influx into vascular smooth muscle and cardiac muscle; peripheral arterial vasodilator.