سعر امبيفلوكس 250 مجم/5مل معلق 60 مل 2024

Ampicillin + flucloxacillin oral suspension listed as 250 mg/5 ml (total), 60 ml bottle; penicillin antibiotic combination.

• Reported adverse reactions include C. difficile-associated diarrhea; gastrointestinal effects (glossitis, stomatitis, nausea, vomiting, enterocolitis, pseudomembranous colitis, diarrhea); a fairly frequent erythematous, mildly pruritic maculopapular rash; other hypersensitivity reactions (urticaria, pruritus, erythema multiforme, exfoliative dermatitis, linear IgA bullous dermatosis, SJS/TEN/DRESS/AGEP, angioedema) and anaphylaxis.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Common: minor gastrointestinal disturbances; uncommon: rash, urticaria, purpura; very rare: hepatitis and cholestatic jaundice, pseudomembranous colitis, blood disorders, anaphylaxis, SJS/TEN, interstitial nephritis; not known: hypokalaemia, AGEP.General active-ingredient information · electronic medicines compendium (emc), UK

• Serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or other beta-lactam antibacterials; infections caused by penicillinase-producing organisms; previous cholestatic jaundice/hepatic dysfunction associated with ampicillin.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to flucloxacillin, any excipient or other beta-lactam antibiotics (penicillins, cephalosporins); previous flucloxacillin-associated jaundice/hepatic dysfunction.General active-ingredient information · electronic medicines compendium (emc), UK

• Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have occurred with penicillins, more often in patients with a history of penicillin hypersensitivity or multiple allergies; cross-reactions with cephalosporins are reported. Ask about previous reactions to penicillins, cephalosporins and other allergens before starting; stop the drug if an allergic reaction occurs; serious anaphylaxis requires emergency treatment (epinephrine, oxygen, IV corticosteroids, airway management).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Severe cutaneous adverse reactions (toxic epidermal necrolysis, Stevens-Johnson syndrome, DRESS, exfoliative dermatitis, erythema multiforme, AGEP) can occur; monitor patients who develop a rash and stop the drug if lesions progress.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhea has been reported with nearly all antibacterial agents and may range from mild diarrhea to fatal colitis; it can occur more than two months after treatment. Consider it in any patient with diarrhea after antibacterial use.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• A high percentage (43-100%) of patients with infectious mononucleosis who receive ampicillin develop a generalized, pruritic maculopapular rash; ampicillin is not recommended in mononucleosis. Superinfection with fungi or resistant bacteria is possible.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Hepatitis and cholestatic jaundice, unrelated to dose or route, may be delayed up to two months after treatment and can be prolonged or (very rarely) fatal; use with caution in hepatic dysfunction, patients over 50 years and those with serious underlying disease.General active-ingredient information · electronic medicines compendium (emc), UK
• Acute generalised exanthematous pustulosis (AGEP) - stop flucloxacillin and do not re-administer; anaphylaxis possible; high anion gap metabolic acidosis with concomitant paracetamol in patients with risk factors; potentially life-threatening hypokalaemia at high doses; special caution in newborns (hyperbilirubinaemia).General active-ingredient information · electronic medicines compendium (emc), UK

• AllopurinolConcurrent use substantially increases the incidence of skin rash compared with ampicillin alone.DailyMed (U.S. National Library of Medicine)
• Bacteriostatic antibiotics (chloramphenicol, erythromycins, sulfonamides, tetracyclines)May interfere with the bactericidal effect of penicillins (shown in vitro; clinical significance not well documented).DailyMed (U.S. National Library of Medicine)
• Oral contraceptivesMay be less effective, and breakthrough bleeding may increase.DailyMed (U.S. National Library of Medicine)
• ProbenecidDecreases renal tubular secretion of ampicillin, increasing blood levels and/or the risk of ampicillin toxicity.DailyMed (U.S. National Library of Medicine)
• Probenecid, sulfinpyrazoneSlow the renal tubular excretion of flucloxacillin.electronic medicines compendium (emc), UK
• MethotrexateFlucloxacillin reduces methotrexate excretion, which can cause methotrexate toxicity.electronic medicines compendium (emc), UK
• WarfarinRare altered INR; monitor prothrombin time/INR when flucloxacillin is added or withdrawn.electronic medicines compendium (emc), UK
• ParacetamolConcurrent use has been associated with high anion gap metabolic acidosis, especially in patients with risk factors; monitor closely.electronic medicines compendium (emc), UK
• VoriconazoleFlucloxacillin can markedly decrease voriconazole levels; monitor for loss of efficacy.electronic medicines compendium (emc), UK
• Oral typhoid vaccineMay be inactivated by flucloxacillin.electronic medicines compendium (emc), UK

• Animal reproduction studies showed no impaired fertility or fetal harm, but there are no adequate and well-controlled studies in pregnant women; use in pregnancy only if clearly needed.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Animal studies showed no teratogenic effects and limited human data show no untoward effects; use in pregnancy only when potential benefits outweigh risks.General active-ingredient information · electronic medicines compendium (emc), UK
• Ampicillin-class antibiotics are excreted in milk and may sensitize the infant; use with caution in nursing women.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Trace amounts pass into breast milk; consider possible hypersensitivity in the infant and use only when benefits outweigh risks.General active-ingredient information · electronic medicines compendium (emc), UK

• In prolonged or high-dose therapy, periodically evaluate renal, hepatic and hematopoietic function. In gonorrhea, rule out syphilis (darkfield examination of suspected lesions; monthly serology for four months otherwise).General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ampicillin: Bactericidal semisynthetic penicillin that acts through inhibition of bacterial cell-wall biosynthesis; active against penicillin-susceptible Gram-positive organisms and many common Gram-negative pathogens; not stable to penicillinases (US ampicillin labels).
• Flucloxacillin: Isoxazolyl penicillin of the beta-lactam group with bactericidal activity against many Gram-positive organisms, including beta-lactamase-producing staphylococci and streptococci (UK SmPC).