سعر ابيكسيدون apexidone‏ 1مجم 20 قرص 2026

psychiatric.antipsychotics

• Common: parkinsonism, akathisia, dystonia, tremor, sedation/somnolence, dizziness, anxiety, blurred vision, nausea, vomiting, abdominal pain, dyspepsia, constipation, increased appetite, weight gain, fatigue, rhinitis and hyperprolactinaemia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to risperidone, paliperidone or any excipient.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: increased mortality in elderly patients with dementia-related psychosis; not approved for this use. Cerebrovascular adverse events in elderly dementia patients.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Neuroleptic malignant syndrome, tardive dyskinesia, metabolic changes (hyperglycaemia/diabetes, dyslipidaemia, weight gain), hyperprolactinaemia, orthostatic hypotension, leukopenia/neutropenia/agranulocytosis, cognitive and motor impairment, seizures, dysphagia and priapism.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP2D6 inhibitors (e.g. fluoxetine, paroxetine)Increase risperidone plasma levels; reduce risperidone dose.DailyMed (U.S. National Library of Medicine)
• Enzyme inducers (e.g. carbamazepine)Decrease risperidone plasma levels; increase risperidone dose as needed.DailyMed (U.S. National Library of Medicine)
• Levodopa and dopamine agonistsRisperidone may antagonise their effects.DailyMed (U.S. National Library of Medicine)

• Neonates exposed to antipsychotics in the third trimester are at risk of extrapyramidal and/or withdrawal symptoms; available data do not establish a drug-associated risk of major malformations.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Risperidone and 9-hydroxyrisperidone are present in human milk; sedation, failure to thrive, jitteriness and extrapyramidal symptoms reported in breastfed infants - monitor.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Risperidone: Mechanism in schizophrenia unclear; therapeutic activity may be mediated through combined dopamine D2 and serotonin 5-HT2 receptor antagonism; clinical effect results from risperidone plus its active metabolite 9-hydroxyrisperidone (paliperidone).