سعر اريبيبرازول aripiprazole‏ 1مجم/مل محلول بالفم 120 مل 2026

psychiatric.antipsychotics

• Commonly observed adverse reactions (>=5% and at least twice placebo) in adults include akathisia; in bipolar mania also sedation, restlessness, tremor and extrapyramidal disorder; in adjunctive MDD also insomnia, constipation, fatigue and blurred vision.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Contraindicated in patients with a history of hypersensitivity to aripiprazole (reactions from pruritus/urticaria to anaphylaxis).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: elderly patients with dementia-related psychosis treated with antipsychotics have an increased risk of death; aripiprazole is not approved for dementia-related psychosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: antidepressants increased suicidal thoughts and behaviours in children, adolescents and young adults; monitor all patients for clinical worsening and emergence of suicidality.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Warnings include cerebrovascular events in elderly dementia patients, neuroleptic malignant syndrome, tardive dyskinesia, metabolic changes (hyperglycaemia/diabetes, dyslipidaemia, weight gain), pathological gambling and other compulsive behaviours, orthostatic hypotension, leukopenia/neutropenia/agranulocytosis, seizures and cognitive/motor impairment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors (e.g. itraconazole, clarithromycin) or strong CYP2D6 inhibitors (e.g. quinidine, fluoxetine, paroxetine)Increase aripiprazole exposure; reduce aripiprazole dose to half (to a quarter if both strong CYP2D6 and CYP3A4 inhibitors).DailyMed (U.S. National Library of Medicine)
• Strong CYP3A4 inducers (e.g. carbamazepine, rifampin)Decrease aripiprazole exposure; double the usual dose over 1 to 2 weeks.DailyMed (U.S. National Library of Medicine)

• Neonates exposed to antipsychotics in the third trimester are at risk of extrapyramidal and/or withdrawal symptoms; epidemiological data have not established a drug-associated risk of major birth defects, miscarriage or adverse maternal outcomes; exposure may decrease post-partum milk supply.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Aripiprazole is present in human milk and may cause clinically relevant decreases in milk supply; monitor the breastfed infant for dehydration and lack of appropriate weight gain.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Aripiprazole: Mechanism in schizophrenia and bipolar I disorder is not fully known; efficacy may be mediated by partial agonism at dopamine D2 and serotonin 5-HT1A receptors combined with antagonism at 5-HT2A receptors (US prescribing information).