سعر افروفيمين 100مجم 30 قرص 2023

• Treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) not due to a co-existing condition, relationship problems or medication effectsPopulation: Premenopausal women (not for postmenopausal women or men)DailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (>=2% and higher than placebo): dizziness, somnolence, nausea, fatigue, insomnia and dry mouth.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Adverse reactions most often leading to discontinuation: dizziness, nausea, insomnia, somnolence and anxiety.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant use with moderate or strong CYP3A4 inhibitors.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic impairment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Known hypersensitivity to flibanserin or any component (anaphylaxis, angioedema reported).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: hypotension and syncope with alcohol, with moderate or strong CYP3A4 inhibitors, and in hepatic impairment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypotension and syncope can occur with flibanserin alone, especially within hours of dosing; taking it at bedtime reduces the risk; avoid driving until at least 6 hours after dosing.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• CNS depression (somnolence, sedation) increases with other CNS depressants.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Moderate or strong CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, fluconazole, diltiazem, verapamil, grapefruit juice)Contraindicated: markedly increased flibanserin exposure with severe hypotension and syncope.DailyMed (U.S. National Library of Medicine)
• AlcoholIncreased risk of severe hypotension and syncope; follow the timing rules.DailyMed (U.S. National Library of Medicine)
• Strong CYP3A4 inducers (e.g. rifampin)Substantially reduced flibanserin exposure; concomitant use not recommended.DailyMed (U.S. National Library of Medicine)

• No studies in pregnant women; in animals fetal toxicity (decreased fetal weight, structural anomalies, fetal loss) occurred only with significant maternal toxicity at exposures more than 15 times the human exposure; animal studies cannot rule out fetal harm.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment (unknown presence in human milk; excreted in rat milk; potential for serious adverse reactions such as sedation in the infant).International label, same formulation · DailyMed (U.S. National Library of Medicine)

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