سعر ارجيدرم-بي كريم 15 جم 2022

Argiderm-P cream, 15 g tube (Amoun Pharmaceutical, Egypt): silver sulfadiazine 1% with panthenol 5% in a washable cream base, used topically for burns, wounds and ulcers (composition as reported by secondary sources).

• Transient leukopenia (mainly decreased neutrophils) has been reported, with maximal depression within 2 to 4 days of starting therapy and recovery within 2 to 3 days that is not influenced by continuing treatment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Other infrequent events: skin necrosis, erythema multiforme, skin discoloration, burning sensation, rashes and interstitial nephritis.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Contraindicated in patients hypersensitive to silver sulfadiazine or any other ingredient of the preparation.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Should not be used in pregnant women approaching or at term, in premature infants, or in newborn infants during the first 2 months of life, because sulfonamides increase the risk of kernicterus.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Absorption varies with the percentage of body surface area treated and the extent of tissue damage; any adverse reaction associated with sulfonamides may occur (e.g. blood dyscrasias, severe skin reactions such as SJS/TEN and exfoliative dermatitis, hepatitis, CNS reactions, toxic nephrosis).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Possible cross-sensitivity with other sulfonamides; if an allergic reaction occurs, continuation must be weighed against the hazard of the reaction.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Fungal proliferation in and below the eschar may occur, although clinically reported fungal superinfection is uncommon.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Use in some patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency may be hazardous because haemolysis may occur.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• If hepatic and renal function become impaired and elimination decreases, accumulation may occur; discontinuation should be weighed against the therapeutic benefit.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• For topical use only; avoid contact with the eyes.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• CimetidineAn increased incidence of leukopenia has been reported in patients treated concurrently with cimetidine.DailyMed (U.S. National Library of Medicine)
• Topical proteolytic enzymesSilver may inactivate topical proteolytic (debriding) enzymes used at the same time.DailyMed (U.S. National Library of Medicine)

• Reproduction studies in rabbits showed no evidence of fetal harm, but there are no adequate and well-controlled studies in pregnant women; use in pregnancy only if clearly justified.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• It is not known whether silver sulfadiazine is excreted in human milk, but sulfonamides are and may increase the risk of kernicterus; decide whether to discontinue nursing or the drug, considering its importance to the mother.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• In burns involving extensive body areas, serum sulfa concentrations may approach adult therapeutic levels: monitor serum sulfa concentrations, monitor renal function carefully and check the urine for sulfa crystals.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Silver sulfadiazine: Silver sulfadiazine is bactericidal for many Gram-negative and Gram-positive bacteria and is also active against yeast; it acts on the bacterial cell membrane and cell wall (mechanism differs from silver nitrate and sodium sulfadiazine).
• Panthenol: Penetrates skin and mucosa and is oxidised to pantothenic acid, a hygroscopic compound and a precursor of coenzyme A (source: Farmaco UAE monograph text).