سعر بلهارزين 600 مجم 4 أقراص مغلفة 2022

Praziquantel 600 mg film-coated tablets for schistosomiasis and susceptible fluke infections (Egyptian El Nasr product).

• Treatment of schistosomiasis due to all Schistosoma species, and clonorchiasis/opisthorchiasis due to Clonorchis sinensis and Opisthorchis viverrini, in patients aged 1 year and older.DailyMed / Bayer

• Malaise, headache, dizziness, abdominal discomfort (with or without nausea), pyrexia, urticaria; post-marketing includes arrhythmia, hypersensitivity, hepatitis, seizures.International label, same formulation · DailyMed / Bayer

• Hypersensitivity to praziquantel or excipients; ocular cysticercosis; concomitant strong CYP3A inducers such as rifampin.International label, same formulation · DailyMed / Bayer

• Clinical deterioration possible in acute schistosomiasis; may exacerbate CNS pathology (epilepsy/cysticercosis history); cardiac arrhythmias reported; monitor hepatosplenic patients with moderate–severe hepatic impairment; avoid moderate CYP3A inducers (e.g. efavirenz).International label, same formulation · DailyMed / Bayer

• Strong CYP3A inducers (e.g. rifampin)MajorContraindicated: strong CYP3A inducers markedly decrease praziquantel levels; therapeutic levels unlikely.DailyMed / Bayer
• Moderate CYP3A inducers (e.g. efavirenz)MajorAvoid concomitant use; clinically significant decrease in praziquantel exposure and possible loss of efficacy.DailyMed / Bayer

• Published studies have not identified an association with praziquantel use in pregnancy and major birth defects, miscarriage, or adverse maternal/fetal outcomes. Animal studies at relevant doses did not show adverse developmental outcomes.International label, same formulation · DailyMed / Bayer
• Praziquantel is present in human milk at low concentrations; effects on the breastfed infant and milk production unknown. Weigh benefits of breastfeeding against mother's need for therapy.International label, same formulation · DailyMed / Bayer

• Praziquantel: Induces rapid contraction of schistosomes via effects on cell-membrane permeability; causes vacuolization and tegument disintegration.