سعر كالسيوم فولينيت 30مجم/10مل امبولات 2022

Calcium folinate 30mg/10ml amp (Orion Pharma (Finland) > S.M. Pharma); calcium folinate (leucovorin) injectable.

• Leucovorin rescue after high-dose methotrexate in osteosarcoma; diminish toxicity of impaired MTX elimination or folic acid antagonist overdose; megaloblastic anemia due to folate deficiency when oral therapy not feasible; with 5-FU for palliative advanced colorectal cancer.Population: As labelled (oncology / folate deficiency)DailyMed (U.S. NLM)

• Allergic sensitization including anaphylactoid reactions and urticaria; anaphylaxis including shock reported. With 5-FU combination: stomatitis, diarrhea, leukopenia and other 5-FU-like toxicities may be more severe.International label, same formulation · DailyMed (U.S. NLM)

• Improper therapy for pernicious anemia and other megaloblastic anemias secondary to vitamin B12 deficiency (hematologic remission may occur while neurologic disease progresses).International label, same formulation · DailyMed (U.S. NLM)

• Do not administer leucovorin intrathecally (may be harmful or fatal). Because of calcium content, IV rate ≤160 mg leucovorin/minute. Enhances 5-FU toxicity—reduce 5-FU dose and monitor GI toxicity. Monitor MTX levels to guide rescue.International label, same formulation · DailyMed (U.S. NLM)

• 5-FluorouracilMajorLeucovorin enhances 5-FU cytotoxicity and GI toxicity; use lower 5-FU doses; do not mix in same infusion.DailyMed (U.S. NLM)
• Trimethoprim-sulfamethoxazoleModerateConcomitant use for PCP in HIV was associated with increased treatment failure and morbidity in a placebo-controlled study.DailyMed (U.S. NLM)

• US label Pregnancy Category C (historical): animal studies inadequate; give only if clearly needed.International label, same formulation · DailyMed (U.S. NLM)
• Unknown whether excreted in human milk; caution when administered to a nursing mother.International label, same formulation · DailyMed (U.S. NLM)

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