سعر كامبتو 300 مجم مركز فيال 20 مجم/مل 2024

Irinotecan 20 mg/ml (300 mg) concentrate for IV infusion, 1 vial (300 mg total) (Pfizer).

• First-line therapy in combination with 5-fluorouracil and leucovorin for metastatic carcinoma of the colon or rectum (US CAMPTOSAR).Population: Adults with metastatic colorectal cancerDailyMed / FDA
• Patients with metastatic colorectal carcinoma whose disease has recurred or progressed following initial fluorouracil-based therapy (US CAMPTOSAR).Population: Adults after fluorouracil-based therapyDailyMed / FDA

• Hypersensitivity to CAMPTOSAR or its excipients (US CAMPTOSAR).International label, same formulation · DailyMed / FDA

• BOXED WARNING — Diarrhea and myelosuppression: early and late diarrhea can occur; late diarrhea can be life-threatening and should be treated promptly with loperamide; monitor and give fluids/electrolytes; interrupt CAMPTOSAR for grade 3–4 diarrhea or neutropenia as labeled (US CAMPTOSAR).International label, same formulation · DailyMed / FDA
• Early diarrhea may be accompanied by cholinergic symptoms; consider atropine 0.25–1 mg IV/SC unless contraindicated (US CAMPTOSAR).International label, same formulation · DailyMed / FDA

• Irinotecan can cause fetal harm; advise females of reproductive potential of risk and use effective contraception per US label counseling (US CAMPTOSAR — see full label).International label, same formulation · DailyMed / FDA

• Irinotecan: Irinotecan and its active metabolite SN-38 bind to topoisomerase I–DNA complex and prevent religation of single-strand breaks, causing lethal DNA damage in replicating cells (US CAMPTOSAR).