سعر كادويت 5/10 مجم 2022

Egyptian Caduet film-coated tablets containing amlodipine 5 mg and atorvastatin 10 mg (Pfizer), pack of 7 tablets.

• CADUET is indicated in patients for whom treatment with both amlodipine and atorvastatin is appropriate. Amlodipine: hypertension and coronary artery disease. Atorvastatin: reduction of cardiovascular risk and treatment of hyperlipidaemia per US label.Population: AdultsDailyMed

• Most common adverse reaction to amlodipine is dose-related edema. Most common adverse reactions (>=5%) to atorvastatin include nasopharyngitis, arthralgia, diarrhea, pain in extremity, and urinary tract infection.International label, same formulation · DailyMed

• Acute liver failure or decompensated cirrhosis; hypersensitivity to amlodipine, atorvastatin or any CADUET excipient.International label, same formulation · DailyMed

• Myopathy and rhabdomyolysis: risk factors include age >=65 years, uncontrolled hypothyroidism, renal impairment, interacting drugs, and higher dosage. Discontinue if markedly elevated CK or myopathy is diagnosed or suspected.International label, same formulation · DailyMed

• Drugs / grapefruit juice that increase myopathy risk with atorvastatinMajorIncreased risk of myopathy and rhabdomyolysis; see full USPI for interacting drugs. Management: Avoid or adjust per USPI; monitor for muscle symptoms.DailyMed

• May cause fetal harm. Advise pregnant patients and patients who can become pregnant of the potential risk to a fetus; discuss discontinuation if pregnancy is known or suspected. Breastfeeding not recommended during treatment with CADUET.International label, same formulation · DailyMed

• Amlodipine: Inhibits transmembrane calcium influx into vascular smooth muscle and cardiac muscle; peripheral arterial vasodilator.
• Atorvastatin: Inhibits HMG-CoA reductase, reducing hepatic cholesterol synthesis.