سعر سيبروفلوكسميت 500/500مجم 20 قرص مغلف 2024

Ciprofloxacin + Metronidazole 500 mg / 500 mg Film-coated tablet (Ciprofloxmet 500/500mg 20 f.c.tabs., HP Pharma, Egypt); Box of 20 film-coated tablets.

• Skin and skin structure infections.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Bone and joint infections.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Complicated intra-abdominal infections (in combination with metronidazole).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most frequently reported adverse reactions (all formulations): nausea (2.5%), diarrhoea (1.6%), abnormal liver function tests (1.3%), vomiting (1%) and rash (1%).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to ciprofloxacin, any member of the quinolone class or any product component.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Concomitant administration with tizanidine.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Combination carries fluoroquinolone class warnings plus metronidazole warnings (disulfiram-like reaction with alcohol; neurologic toxicity; avoid in first trimester for trichomoniasis per older US labels).General active-ingredient information · DailyMed (U.S. National Library of Medicine), PubChem
• Boxed warning: fluoroquinolones have been associated with disabling and potentially irreversible serious adverse reactions occurring together, including tendinitis and tendon rupture, peripheral neuropathy and central nervous system effects; discontinue immediately and avoid fluoroquinolones in patients who experience them.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: may exacerbate muscle weakness in patients with myasthenia gravis; avoid in patients with a known history of myasthenia gravis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• TizanidineContraindicated: potentiation of the hypotensive and sedative effects of tizanidine.DailyMed (U.S. National Library of Medicine)
• TheophyllineAvoid use: increased and prolonged theophylline exposure with serious and fatal reactions; if unavoidable, monitor serum theophylline and adjust the dose.DailyMed (U.S. National Library of Medicine)
• Drugs known to prolong the QT interval (e.g. class IA or III antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics)Avoid use: ciprofloxacin may further prolong the QT interval.DailyMed (U.S. National Library of Medicine)

• Prolonged experience with ciprofloxacin in pregnant women over several decades (case reports, case-control and observational studies) has not identified any drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Ciprofloxacin is present in human milk; because of potential serious adverse reactions in breastfed infants (including arthropathy in juvenile animals), a woman may pump and discard milk during treatment and for 2 more days after the last dose, or not breastfeed during that time.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Ciprofloxacin: Bactericidal fluoroquinolone that inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, blocking DNA replication.
• Metronidazole: After passive diffusion into susceptible anaerobes it is reduced intracellularly (via electron-transport proteins such as ferredoxin) to a short-lived nitroso free radical; the reduced drug and free radicals can interact with DNA, inhibiting DNA synthesis and causing DNA degradation and bacterial death; the precise mechanism is unclear (US label).