سعر كومتابون 200 مجم 30 قرص مغلف 2026

Comtapone 200 mg film-coated tablets × 30: entacapone COMT inhibitor adjunct to levodopa/carbidopa (Chemipharm).

• Adjunct to levodopa/carbidopa to treat end-of-dose “wearing-off” in Parkinson’s disease. Effectiveness not systematically evaluated in patients without wearing-off (US label).Population: Adults with Parkinson’s disease and end-of-dose wearing-offDailyMed (U.S. National Library of Medicine)

• Most common (≥3% above placebo): dyskinesia, urine discoloration, diarrhea, nausea, hyperkinesia, abdominal pain, vomiting, dry mouth (US controlled studies).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to entacapone or tablet ingredients (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Do not combine with non-selective MAO inhibitors (e.g. phenelzine, tranylcypromine); selective MAO-B (e.g. selegiline) may be co-administered (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• May cause or worsen dyskinesia; sudden sleep onset; orthostatic hypotension; hallucinations/psychotic-like behavior; impulse-control disorders; diarrhea/colitis; urine brownish-orange discoloration (not clinically harmful) (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Non-selective MAO inhibitorsMajorConcomitant use ordinarily avoided — theoretical complete catecholamine pathway block (US label).DailyMed (U.S. National Library of Medicine)
• Drugs metabolized by COMT (e.g. isoproterenol, epinephrine, dopamine, dobutamine)ModerateMay increase heart rate, arrhythmias, BP changes; administer with caution (US label).DailyMed (U.S. National Library of Medicine)
• WarfarinModerateMonitor INR when starting or increasing entacapone (US label postmarketing).DailyMed (U.S. National Library of Medicine)

• Use during pregnancy only if potential benefit justifies potential risk to fetus; always given with levodopa/carbidopa which is teratogenic in rabbits; animal data showed fetal variations/eye anomalies at high exposures; no adequate human studies (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Unknown if excreted in human milk; excreted in rat milk — caution in nursing women (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Entacapone: Inhibits peripheral COMT, prolonging levodopa plasma half-life when given with levodopa/DDI.