سعر كريدوسان 100 مجم 2 قرص مغلف 2022

Credosan 100 mg film-coated tablets ×2: sumatriptan for acute migraine (Marcyrl / Pharma Credo).

• Acute treatment of migraine with or without aura in adultsPopulation: AdultsDailyMed (FDA SPL)

• Most common (≥2% and >placebo): paresthesia, warm/cold sensation, chest/neck/throat/jaw pain-tightness-pressure, other pressure sensations, vertigo, malaise/fatigue.International label, same formulation · DailyMed (FDA SPL)

• Ischemic coronary artery disease, coronary vasospasm (including Prinzmetal), Wolff-Parkinson-White or other accessory pathway arrhythmias.International label, same formulation · DailyMed (FDA SPL)
• History of stroke/TIA, hemiplegic or basilar migraine; peripheral vascular disease; ischemic bowel disease; uncontrolled hypertension.International label, same formulation · DailyMed (FDA SPL)
• Recent (within 24 h) use of another 5-HT1 agonist or ergotamine-containing medication; concurrent or recent (2 weeks) MAO-A inhibitor; hypersensitivity to sumatriptan; severe hepatic impairment.International label, same formulation · DailyMed (FDA SPL)

• Myocardial ischemia/infarction and Prinzmetal angina: perform cardiac evaluation in patients with multiple CV risk factors before use.International label, same formulation · DailyMed (FDA SPL)
• Serotonin syndrome risk with SSRIs/SNRIs/TCAs/MAOIs; medication-overuse headache with frequent acute migraine drug use; seizures — use caution if epilepsy or lowered seizure threshold.International label, same formulation · DailyMed (FDA SPL)

• Ergotamine / ergot-type drugsMajorAdditive vasospasm; contraindicated within 24 hours of each other.DailyMed (FDA SPL)
• MAO-A inhibitorsMajorIncrease sumatriptan exposure (~7-fold orally); contraindicated concurrently or within 2 weeks.DailyMed (FDA SPL)
• Other 5-HT1 agonists (triptans)MajorContraindicated within 24 hours due to additive vasospasm.DailyMed (FDA SPL)

• Human data from registries/epidemiology have not detected an increased frequency of birth defects vs general population; animal data showed embryolethality/fetal abnormalities at high exposures. Discuss risks/benefits.International label, same formulation · DailyMed (FDA SPL)
• Sumatriptan is excreted in human milk after SC use; tablet milk data limited. Avoid breastfeeding for 12 hours after a dose to minimize infant exposure; transient breast pain reported.International label, same formulation · DailyMed (FDA SPL)

• Sumatriptan: Agonist at 5-HT1B/1D receptors on intracranial vessels and trigeminal sensory nerves, causing cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release.