سعر كريندانون جل موضعي 30 جم 2023

Crendanone topical gel 30 g: clindamycin 1.2% + tretinoin 0.025% for acne (EGPI / Pharma Three).

• Topical treatment of acne vulgaris in patients 12 years or olderPopulation: Patients ≥12 yearsDailyMed (FDA SPL)

• Local reactions: erythema, scaling, itching, burning, stinging. Other ≥1%: nasopharyngitis, pharyngolaryngeal pain, dry skin, cough, sinusitis.International label, same formulation · DailyMed (FDA SPL)

• Regional enteritis, ulcerative colitis, or history of antibiotic-associated colitis.International label, same formulation · DailyMed (FDA SPL)

• Colitis: systemic absorption of clindamycin can cause severe colitis which may be fatal; discontinue if significant diarrhea occurs.International label, same formulation · DailyMed (FDA SPL)
• Ultraviolet light and environmental exposures: avoid sunlight/sunlamps; wear sunscreen daily; weather extremes may irritate.International label, same formulation · DailyMed (FDA SPL)

• Erythromycin-containing productsMajorDo not use with erythromycin-containing products (antagonism with clindamycin in vitro).DailyMed (FDA SPL)
• Strongly drying topical products / alcohol astringentsModerateMay increase skin irritation when used with ZIANA-type gels; use caution.DailyMed (FDA SPL)

• No well-controlled trials in pregnant women; use only if potential benefit justifies potential fetal risk (US label Pregnancy Category C historical framework on ZIANA).International label, same formulation · DailyMed (FDA SPL)
• Oral/parenteral clindamycin appears in breast milk; unknown for topical. Decide whether to discontinue nursing or the drug. Unknown if tretinoin is excreted in human milk — caution.International label, same formulation · DailyMed (FDA SPL)

• Clindamycin (as phosphate): Binds 50S ribosomal subunit and inhibits bacterial protein synthesis; activity against Cutibacterium acnes.
• Tretinoin: Decreases cohesiveness of follicular epithelial cells and increases turnover, promoting comedone extrusion.