سعر كوبريبن 250 مجم 30 كبسولة 2024

Cupripen 250mg 30caps.: Penicillamine (Laboratorios Rubio > Egyptian Pharmaceutical Trading Company).

• Wilson’s disease; cystinuria; severe active rheumatoid arthritis unresponsive to conventional therapy (US CUPRIMINE). Not of value in ankylosing spondylitis.Population: Specialist use — Wilson / cystinuria / severe RADailyMed (U.S. National Library of Medicine)

• High incidence of untoward reactions including rash, taste alteration, proteinuria, hematologic cytopenias, GI effects — some potentially fatal (US CUPRIMINE).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Pregnancy (except Wilson’s or certain cystinuria cases); nursing mothers should not breastfeed; history of penicillamine-related aplastic anemia or agranulocytosis — do not restart (US CUPRIMINE).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fatalities reported (aplastic anemia, agranulocytosis, thrombocytopenia, Goodpasture’s, myasthenia). Mandatory close monitoring: urinalysis, CBC with differential, hemoglobin, platelets throughout therapy (US CUPRIMINE).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm (teratogenic in animals); contraindicated in pregnancy except for Wilson’s disease or certain cystinuria patients where benefit may outweigh risk (US CUPRIMINE).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Mothers on penicillamine should not nurse (US CUPRIMINE).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Penicillamine: Chelates copper and other heavy metals; also used as a DMARD in severe rheumatoid arthritis.