سعر ريتاديل 250مجم 20 كبسول 2022

Penicillamine 250 mg capsules, 20 per pack (Delta Pharma); chelating agent used for Wilson's disease, cystinuria and severe rheumatoid arthritis.

• Wilson's disease.DailyMed (U.S. National Library of Medicine)
• Cystinuria.DailyMed (U.S. National Library of Medicine)
• Severe, active rheumatoid arthritis in patients who failed an adequate trial of conventional therapy.DailyMed (U.S. National Library of Medicine)

• Allergic: pruritus, early and late rashes (5%), pemphigus, drug eruptions, lupus-like syndrome.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Gastrointestinal: anorexia, epigastric pain, nausea, vomiting or diarrhea (17%); taste blunting or loss (12%); oral ulcerations.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hematological: bone marrow depression, leukopenia (2%), thrombocytopenia (4%); fatal agranulocytosis and aplastic anemia reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Pregnancy, except for treatment of Wilson's disease or certain patients with cystinuria.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Nursing mothers should not breastfeed during therapy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• History of penicillamine-related aplastic anemia or agranulocytosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fatalities have been associated with aplastic anemia, agranulocytosis, thrombocytopenia, Goodpasture's syndrome and myasthenia gravis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Drug fever, sometimes with rash, may occur in the second to third week of therapy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Penicillamine increases pyridoxine requirement; patients may need a daily pyridoxine supplement.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Food, antacids and ironReduce penicillamine absorption; separate administration by at least 1 hour from other drugs, food or milk.DailyMed (U.S. National Library of Medicine)

• Penicillamine can cause fetal harm; congenital cutis laxa and associated birth defects have been reported after in-utero exposure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Mothers on penicillamine therapy should not nurse their infants.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Penicillamine: Chelates copper for urinary excretion in Wilson's disease and forms soluble penicillamine-cysteine disulfide, reducing cystine excretion in cystinuria (US label).