سعر انبريل 25مجم 4 سرنجات معبأة للحقن 2024

Enbrel (etanercept) 25 mg solution for subcutaneous injection in pre-filled syringe, pack of 4 syringes (Pfizer). TNF-blocker biologic for inflammatory arthritides and plaque psoriasis.

• Moderate to severe active rheumatoid arthritis in adults (with methotrexate, or as monotherapy if methotrexate is not tolerated/inappropriate); severe progressive RA not previously treated with methotrexate.Population: AdultsEuropean Medicines Agency (EMA)
• Polyarticular juvenile idiopathic arthritis (2 years and older), juvenile psoriatic arthritis, adult psoriatic arthritis, ankylosing spondylitis and plaque psoriasis (adults and children 4 years and older).Population: Adults and childrenDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions: infections and injection-site reactions; most serious: infections, neurologic events, congestive heart failure and haematologic events.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to etanercept or excipients; sepsis or risk of sepsis; treatment should not be initiated in patients with active infections, including chronic or localised infections.International label, same product · European Medicines Agency (EMA)
• Contraindicated in patients with sepsis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: increased risk of serious infections leading to hospitalisation or death (tuberculosis, bacterial sepsis, invasive fungal and opportunistic infections); discontinue if a serious infection or sepsis develops; test for latent TB before and monitor during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: lymphoma and other malignancies, some fatal, reported in children and adolescents treated with TNF blockers including Enbrel.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• AnakinraConcurrent use increased serious infections (7%) without added benefit.DailyMed (U.S. National Library of Medicine)
• AbataceptConcurrent use increased serious adverse events including infections without added benefit.DailyMed (U.S. National Library of Medicine)
• Live vaccinesLive vaccines should not be given concurrently (US label).DailyMed (U.S. National Library of Medicine)

• Available studies do not reliably support an association between etanercept and major birth defects; registry data showed a higher proportion of major birth defects versus disease-matched unexposed women without a specific pattern. Placental transfer at birth is low; weigh live-vaccine risks for in-utero-exposed infants.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Etanercept is present at low levels in human milk and was not detected in the plasma of breastfed infants; weigh benefits of breastfeeding against maternal need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Etanercept: Dimeric soluble p75 TNF receptor-Fc fusion protein that binds TNF-alpha and TNF-beta, rendering TNF biologically inactive (US label 12.1).