سعر ابيزين 10 مجم فيال 2022

Epirubicin 10 mg vial for intravenous injection/infusion (Epizin; Korea United Pharm, distributed by EIMC).

• Component of adjuvant therapy in patients with axillary node tumor involvement following resection of primary breast cancer.Population: AdultsDailyMed (U.S. NLM)

• Most common (>=10%): leukopenia, neutropenia, anemia, thrombocytopenia, amenorrhea, lethargy, nausea/vomiting, mucositis, diarrhea, infection, conjunctivitis/keratitis, alopecia, local skin toxicity and rash/itch.General active-ingredient information · DailyMed (U.S. NLM)

• Severe myocardial insufficiency; recent myocardial infarction or severe arrhythmias; previous treatment with maximum cumulative anthracycline doses; severe persistent drug-induced myelosuppression; severe hepatic impairment (Child-Pugh C or bilirubin >5 mg/dL); severe hypersensitivity to epirubicin, other anthracyclines or anthracenediones.General active-ingredient information · DailyMed (U.S. NLM)

• Boxed warning - cardiac toxicity: myocardial damage including acute left ventricular failure; cardiomyopathy risk rises with cumulative dose (0.9% at 550 mg/m2, 1.6% at 700 mg/m2, 3.3% at 900 mg/m2).General active-ingredient information · DailyMed (U.S. NLM)
• Boxed warning: secondary AML and myelodysplastic syndrome; severe local tissue necrosis on extravasation (stop the infusion and apply ice); severe myelosuppression with serious infection, septic shock and death.General active-ingredient information · DailyMed (U.S. NLM)

• Can cause fetal harm based on animal data and mechanism; avoid use during the first trimester. Fetal/neonatal cardiotoxicity has been reported after exposure in the 2nd and 3rd trimesters.General active-ingredient information · DailyMed (U.S. NLM)
• No human milk data; present in rat milk. Advise not to breastfeed during treatment and for at least 7 days after the last dose.General active-ingredient information · DailyMed (U.S. NLM)

• Epirubicin: Anthracycline that intercalates DNA and inhibits topoisomerase II, interfering with DNA and RNA synthesis (US Ellence label class description).