سعر ريبوبي 10مجم فيال وريد.عضل 5 مل 2022

Riboepi 10mg vial for i.v. inj./inf. 5ml

معلومات الدواء

دواعي الاستعمالUses

Component of adjuvant therapy in patients with axillary node tumour involvement following resection of primary breast cancer.DailyMed (U.S. National Library of Medicine)

Component of adjuvant therapy in patients with axillary node tumour involvement following resection of primary breast cancer.DailyMed (U.S. National Library of Medicine)

الآثار الجانبيةSide effects

Most common (10% or more): leukopenia, neutropenia, anaemia, thrombocytopenia, amenorrhoea, lethargy, nausea/vomiting, mucositis, diarrhoea, infection, conjunctivitis/keratitis, alopecia, local skin toxicity and rash/itch.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

Most common (10% or more): leukopenia, neutropenia, anaemia, thrombocytopenia, amenorrhoea, lethargy, nausea/vomiting, mucositis, diarrhoea, infection, conjunctivitis/keratitis, alopecia, local skin toxicity and rash/itch.International label, same formulation · DailyMed (U.S. National Library of Medicine)

موانع الاستعمالContraindications

Severe myocardial insufficiency.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Recent myocardial infarction or severe arrhythmias, or previous treatment with maximum cumulative dose of anthracyclines.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Severe persistent drug-induced myelosuppression.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

Severe myocardial insufficiency.International label, same formulation · DailyMed (U.S. National Library of Medicine)
Recent myocardial infarction or severe arrhythmias, or previous treatment with maximum cumulative dose of anthracyclines.International label, same formulation · DailyMed (U.S. National Library of Medicine)
Severe persistent drug-induced myelosuppression.International label, same formulation · DailyMed (U.S. National Library of Medicine)

تحذيرات واحتياطاتWarnings & precautions

Boxed warning - cardiac toxicity: myocardial damage including acute left ventricular failure; cardiomyopathy risk rises with cumulative dose (0.9% at 550 mg/m2, 1.6% at 700 mg/m2, 3.3% at 900 mg/m2).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Boxed warning - secondary AML and myelodysplastic syndrome occur at higher incidence with anthracyclines.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Boxed warning - extravasation can cause severe local tissue injury and necrosis; stop the infusion immediately and apply ice.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

Boxed warning - cardiac toxicity: myocardial damage including acute left ventricular failure; cardiomyopathy risk rises with cumulative dose (0.9% at 550 mg/m2, 1.6% at 700 mg/m2, 3.3% at 900 mg/m2).International label, same formulation · DailyMed (U.S. National Library of Medicine)
Boxed warning - secondary AML and myelodysplastic syndrome occur at higher incidence with anthracyclines.International label, same formulation · DailyMed (U.S. National Library of Medicine)
Boxed warning - extravasation can cause severe local tissue injury and necrosis; stop the infusion immediately and apply ice.International label, same formulation · DailyMed (U.S. National Library of Medicine)

التداخلات الدوائيةDrug interactions

Cardiotoxic agents (e.g. trastuzumab, calcium channel blockers)Increased risk of cardiotoxicity; monitor cardiac function closely and delay epirubicin after long half-life cardiotoxic agents such as trastuzumab.DailyMed (U.S. National Library of Medicine)
CimetidineCimetidine increases epirubicin exposure; discontinue cimetidine during treatment.DailyMed (U.S. National Library of Medicine)

Cardiotoxic agents (e.g. trastuzumab, calcium channel blockers)Increased risk of cardiotoxicity; monitor cardiac function closely and delay epirubicin after long half-life cardiotoxic agents such as trastuzumab.DailyMed (U.S. National Library of Medicine)
CimetidineCimetidine increases epirubicin exposure; discontinue cimetidine during treatment.DailyMed (U.S. National Library of Medicine)

الحمل والرضاعةPregnancy & breastfeeding

Can cause fetal harm based on animal data and mechanism; avoid use during the first trimester; rare reports of fetal/neonatal cardiotoxicity after 2nd/3rd trimester exposure.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Advise not to breastfeed during treatment and for at least 7 days after the last dose.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

Can cause fetal harm based on animal data and mechanism; avoid use during the first trimester; rare reports of fetal/neonatal cardiotoxicity after 2nd/3rd trimester exposure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
Advise not to breastfeed during treatment and for at least 7 days after the last dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)

كيف يعمل الدواءHow it works

Anthracycline topoisomerase inhibitor (US Ellence label: DNA intercalation, topoisomerase II inhibition).

Epirubicin: Anthracycline topoisomerase inhibitor (US Ellence label: DNA intercalation, topoisomerase II inhibition).

نفس المادة الفعالة والتركيز. اسأل الصيدلي قبل الاستبدال.

مثائل ريبوبي 10مجم فيال وريد.عضل 5 مل بنفس المادة الفعالة والتركيز، مرتبة من الأرخص
الدواء	السعر	الفرق عن الأصلي
ريبوبي 50مجم امبول 25ملRiboepi 50mg vial for i.v. inj./inf. 25mlHikma Specialized Pharmaceuticals · 50 mg/25 mlالأرخص	السعر270ج.م270ج.م للوحدة	الفرق عن الأصليأغلى 210ج.م (350%)
ريبوبي 200مجم امبول 100ملRiboepi 200mg vial for i.v. inj./inf. 100mlHikma Specialized Pharmaceuticals · 200 mg/100 ml	السعر900ج.م900ج.م للوحدة	الفرق عن الأصليأغلى 840ج.م (1,400%)

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