سعر ايوبيفالجان 1جم/100مل فيال 100 مل 2022

Paracetamol (acetaminophen) 1 g/100 ml (10 mg/ml) solution for IV infusion, 100 ml vial (Eupifalgan; EIMC).

• Management of mild to moderate pain.Population: Adults and children 2 years and olderDailyMed (U.S. National Library of Medicine)
• Management of moderate to severe pain with adjunctive opioid analgesics.Population: Adults and children 2 years and olderDailyMed (U.S. National Library of Medicine)
• Reduction of fever.Population: Adults and children 2 years and olderDailyMed (U.S. National Library of Medicine)

• Most common in adults: nausea, vomiting, headache and insomnia; in children: nausea, vomiting, constipation, pruritus, agitation and atelectasis.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to acetaminophen or any excipient of the IV formulation; severe hepatic impairment or severe active liver disease.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: risk of medication errors (mg/mL confusion, weight-based dosing under 50 kg, pump programming) and hepatotoxicity; acute liver failure, sometimes requiring transplant or fatal, mostly with doses exceeding daily limits or multiple acetaminophen products.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Use with caution in hepatic impairment or active hepatic disease, alcoholism, chronic malnutrition, severe hypovolaemia or severe renal impairment (CrCl ≤30 ml/min). Discontinue at the first appearance of skin rash or hypersensitivity (serious skin reactions such as SJS/TEN possible).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• CYP2E1 inducers or regulators (e.g. ethanol)Substances that induce or regulate CYP2E1 may alter acetaminophen metabolism and increase its hepatotoxic potential.DailyMed (U.S. National Library of Medicine)
• WarfarinChronic oral acetaminophen 4,000 mg/day has increased INR in some patients stabilised on warfarin.DailyMed (U.S. National Library of Medicine)

• Decades of observational data in pregnant women did not identify a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; no animal reproduction studies with IV acetaminophen.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Acetaminophen is present in human milk in small quantities; consider the benefits of breastfeeding and the mother's need for the drug.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Paracetamol (acetaminophen): Precise analgesic and antipyretic mechanism not established; thought to involve primarily central actions (US acetaminophen injection label).