سعر يوبيفورا 1 مجم / مل 5 امبول 2022

Granisetron 1 mg/1 mL solution for intravenous injection, pack of 5 ampoules.

• Prevention of nausea and/or vomiting associated with initial and repeat courses of emetogenic cancer therapy, including high-dose cisplatin.DailyMed (U.S. NLM)

• Most common adverse reactions (3% or more): headache and constipation; also asthenia, somnolence, diarrhea, fever and elevated liver enzymes.International label, equivalent formulation · DailyMed (U.S. NLM)

• Known hypersensitivity to granisetron or any of its components.International label, equivalent formulation · DailyMed (U.S. NLM)

• Does not stimulate gastric or intestinal peristalsis and may mask progressive ileus or gastric distention; QT prolongation (caution in arrhythmias or conduction disorders); hypersensitivity in patients sensitive to other 5-HT3 antagonists; the 1 mg/mL US product contains benzyl alcohol (gasping syndrome in neonates); serotonin syndrome, especially with serotonergic drugs.International label, equivalent formulation · DailyMed (U.S. NLM)

• QT-prolonging or arrhythmogenic drugsConcomitant use may result in clinical consequences of QT prolongation.DailyMed (U.S. NLM)
• Serotonergic drugs (SSRIs, SNRIs, MAOIs, mirtazapine, fentanyl, lithium, tramadol, IV methylene blue)Risk of serotonin syndrome.DailyMed (U.S. NLM)
• CYP450 inducers or inhibitors (e.g. phenobarbital, ketoconazole)May change granisetron clearance and half-life; phenobarbital increased total clearance by 25%.DailyMed (U.S. NLM)

• No adequate and well-controlled studies in pregnant women; use during pregnancy only if clearly needed. Benzyl alcohol (in the US 1 mg/mL product) may cross the placenta.International label, equivalent formulation · DailyMed (U.S. NLM)
• Not known whether excreted in human milk; use caution in nursing women.International label, equivalent formulation · DailyMed (U.S. NLM)

• Granisetron: Selective 5-HT3 receptor antagonist with little or no affinity for other serotonin, adrenergic, dopamine, histamine, benzodiazepine or opioid receptors; blocks serotonin stimulation of vagal afferents and the chemoreceptor trigger zone (US granisetron label).