سعر فاركوتيليوم 10مجم 24 كبسولة 2024

Domperidone 10 mg oral capsules (Pharco), pack of 24.

• Reported adverse reactions include dry mouth, diarrhoea, somnolence, headache, anxiety, agitation, rash, pruritus, galactorrhoea, breast pain/tenderness, gynaecomastia and amenorrhoea; extrapyramidal disorder, convulsions, QTc prolongation, ventricular arrhythmias and sudden cardiac death have also been reported (see SmPC for frequencies).General active-ingredient information · emc (medicines.org.uk)

• Contraindicated with: hypersensitivity; prolactinoma; phaeochromocytoma; situations where stimulating gastric motility could be harmful (GI haemorrhage, mechanical obstruction, perforation); moderate or severe hepatic impairment; known QTc prolongation, significant electrolyte disturbances or underlying cardiac disease such as congestive heart failure; co-administration with QT-prolonging drugs (except apomorphine) or potent CYP3A4 inhibitors.General active-ingredient information · emc (medicines.org.uk)

• Associated with QT prolongation, torsades de pointes, serious ventricular arrhythmias and sudden cardiac death; higher risk in patients over 60 years, daily doses above 30 mg, and with QT-prolonging drugs or CYP3A4 inhibitors. Use the lowest effective dose.General active-ingredient information · emc (medicines.org.uk)

• QT-prolonging drugs (except apomorphine)Co-administration is contraindicated because of the risk of QT prolongation.emc (medicines.org.uk)
• Potent CYP3A4 inhibitors (e.g. oral ketoconazole, erythromycin)Contraindicated; potent CYP3A4 inhibition markedly increases domperidone exposure (first-pass metabolism inhibition).emc (medicines.org.uk)

• Limited post-marketing data in pregnancy; animal studies showed reproductive toxicity at maternally toxic doses. Use in pregnancy only when justified by the anticipated therapeutic benefit.General active-ingredient information · emc (medicines.org.uk)
• Excreted in human milk (breast-fed infants receive less than 0.1% of the maternal weight-adjusted dose); cardiac adverse effects in the infant cannot be excluded. Decide whether to stop breastfeeding or therapy; caution with QTc risk factors in the infant.General active-ingredient information · emc (medicines.org.uk)

• Consider ECG monitoring in overdose because of possible QT interval prolongation; assess cardiac risk factors and electrolytes before use.General active-ingredient information · emc (medicines.org.uk)

• Domperidone: Dopamine antagonist with anti-emetic properties that does not readily cross the blood-brain barrier (UK domperidone 1 mg/ml oral suspension SmPC).