سعر فلاجيل 0.5% محلول حقن وريدي 100 مل 2023

Flagyl 0.5% (5 mg/ml; 500 mg/100 ml) metronidazole solution for intravenous infusion, 100 ml, Amriya Pharmaceutical Industries for Sanofi, Egypt.

• Treatment of serious infections caused by susceptible anaerobic bacteria (intra-abdominal, skin and skin structure, gynaecological, septicaemia, bone and joint, CNS, lower respiratory tract, endocarditis) and prophylaxis of postoperative infection in contaminated or potentially contaminated elective colorectal surgery.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Reported with metronidazole formulations: nausea, vomiting, abdominal pain, diarrhoea, dysgeusia, decreased appetite, headache, dizziness, vaginal candidiasis; leucopenia, neutropenia, agranulocytosis, thrombocytopenia; encephalopathy, seizures, peripheral neuropathy, ataxia, aseptic meningitis; QT prolongation; pancreatitis; rash, pruritus, urticaria, SJS/TEN; hypersensitivity/anaphylaxis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to metronidazole or other nitroimidazoles; disulfiram within the last 2 weeks; alcohol or propylene glycol products during therapy and for at least 3 days afterwards; Cockayne syndrome.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: carcinogenic in mice and rats — avoid unnecessary use. Encephalopathy, peripheral neuropathy, aseptic meningitis and seizures reported; severe hepatotoxicity in Cockayne syndrome; severe cutaneous reactions; each container provides 14 mEq of sodium (caution with controlled-sodium diets, corticosteroids or oedema-prone patients).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Alcohol / propylene glycolDisulfiram-like reaction; stop alcohol/propylene glycol before, during and up to 72 hours after therapy.DailyMed (U.S. National Library of Medicine)
• DisulfiramPsychotic reactions; avoid within 2 weeks of disulfiram.DailyMed (U.S. National Library of Medicine)
• Warfarin and other oral anticoagulantsPotentiated anticoagulation; monitor INR and signs of bleeding.DailyMed (U.S. National Library of Medicine)

• Metronidazole crosses the placenta; use in pregnancy only if clearly needed.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Present in human milk; a nursing mother may pump and discard milk during therapy and for 24 hours after therapy ends.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Metronidazole: After passive diffusion into susceptible anaerobes it is reduced intracellularly (via electron-transport proteins such as ferredoxin) to a short-lived nitroso free radical; the reduced drug and free radicals can interact with DNA, inhibiting DNA synthesis and causing DNA degradation and bacterial death; the precise mechanism is not fully established.