سعر فراجمين 5000 وحدة دولية / 0.2 مل 10 حقن مسبقة التعبئة 5,000 وحدة دولية/0.2 مل 2022

Dalteparin sodium 5,000 anti-Xa IU in 0.2 ml, single-dose prefilled syringes for subcutaneous injection, pack of 10 (Pfizer); a low molecular weight heparin anticoagulant.

• Prophylaxis of ischaemic complications in unstable angina and non-Q-wave myocardial infarction, with aspirinPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Prophylaxis of deep vein thrombosis in hip replacement surgeryPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Prophylaxis of deep vein thrombosis in abdominal surgery patients at risk of thromboembolic complicationsPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common: injection-site haematoma and haemorrhagic complications (risk varies with indication and dose). Thrombocytopenia (notably in cancer and paediatric VTE trials). Postmarketing: epidural/spinal haematoma, osteoporosis, skin necrosis, alopecia, hyperkalaemia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Active major bleeding; history of heparin-induced thrombocytopenia (with or without thrombosis); hypersensitivity to dalteparin, heparin or pork products; patients undergoing epidural/neuraxial anaesthesia when Fragmin is used for unstable angina/non-Q-wave MI or for prolonged VTE prophylaxis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• BOXED WARNING: epidural or spinal haematomas, possibly causing long-term or permanent paralysis, may occur in patients receiving LMWH with neuraxial anaesthesia or spinal puncture; risk increases with indwelling epidural catheters, concomitant NSAIDs/antiplatelets/anticoagulants, traumatic or repeated punctures and spinal deformity/surgery. Monitor neurological status frequently.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Neuraxial catheter placement/removal should be delayed at least 12 h after 2,500 units once daily and at least 15 h after 5,000 units once daily (24 h after higher doses); consider waiting at least 4 h after catheter removal before the next dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Heparin-induced thrombocytopenia can occur; monitor and closely evaluate thrombocytopenia of any degree.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Oral anticoagulants, platelet inhibitors (incl. aspirin, NSAIDs) and thrombolyticsConcomitant use may increase the risk of bleeding.DailyMed (U.S. National Library of Medicine)

• Published literature and postmarketing reports have not shown a clear association with adverse developmental outcomes; no embryo-fetal toxicity or teratogenicity in rats and rabbits. Untreated VTE carries maternal risk; use in pregnancy only if clearly needed, preferring preservative-free formulations.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Dalteparin is present in human milk in small amounts with low expected oral absorption; no adverse effects on breastfed infants reported. Weigh breastfeeding benefits against maternal need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Dalteparin sodium: Enhances antithrombin-mediated inhibition of factor Xa and thrombin, preferentially factor Xa, with little effect on aPTT.