سعر جاستروبيكسي 10 مجم 28 قرص 2022

Vonoprazan 10 mg tablets, 28 per pack (4 strips), by Apex Pharma.

• Healing of all grades of erosive esophagitis and relief of heartburn; maintenance of healing of erosive esophagitis and relief of heartburn; relief of heartburn associated with non-erosive GERD; treatment of Helicobacter pylori infection in combination with amoxicillin (with or without clarithromycin).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Non-erosive GERD (10 mg): abdominal pain, constipation, diarrhea, nausea and urinary tract infection (each about 2%).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to vonoprazan or any component; patients receiving rilpivirine-containing products. (When used with antibiotics, the antibiotic contraindications also apply.)International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Symptomatic response does not preclude gastric malignancy. Acute tubulointerstitial nephritis, C. difficile-associated diarrhea, bone fracture with long-term use, severe cutaneous adverse reactions, vitamin B12 deficiency, hypomagnesemia and fundic gland polyps have been reported or may occur. Increased chromogranin A can interfere with neuroendocrine tumour testing.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Rilpivirine; drugs dependent on gastric pH for absorptionConcomitant use with rilpivirine-containing products is contraindicated; avoid atazanavir and nelfinavir; reduced gastric acidity may alter absorption of other pH-dependent drugs - see the label.DailyMed (U.S. National Library of Medicine)
• Strong or moderate CYP3A inducersVonoprazan exposure is predicted to be about 80% lower with a strong CYP3A4 inducer (rifampicin) and 50% lower with a moderate inducer (efavirenz), which may reduce efficacy.DailyMed (U.S. National Library of Medicine)

• Available data are insufficient to evaluate a drug-associated risk of major birth defects or miscarriage; a pregnancy exposure registry exists.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• In a lactation study less than 0.03% of the maternal dose reached milk; liver injury was seen in rat offspring exposed through milk. Weigh breastfeeding benefits against risks (the label also notes considerations for clarithromycin/amoxicillin).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Vonoprazan: Potassium-competitive acid blocker: inhibits the parietal-cell H+,K+-ATPase in a potassium-competitive manner, suppressing basal and stimulated acid secretion; does not require activation by acid (US label).