سعر جليبرسين 2024

Glypressin: terlipressin acetate 1 mg/8.5 ml solution for intravenous injection, 5 ampoules (Ferring; Egyptian listing via Multipharma).

• Short-term management of bleeding oesophageal varices.Population: Adultsmedicines.ie (Ferring Ireland Limited / HPRA)
• Emergency treatment of type 1 hepatorenal syndrome (International Ascites Club criteria).Population: Adultsmedicines.ie (Ferring Ireland Limited / HPRA)

• Most frequent: abdominal pain, nausea, diarrhoea, pallor, vomiting, bradycardia, dyspnoea and respiratory failure (type 1 HRS). Others include hyponatraemia, headache, hypertension, peripheral ischaemia, chest pain, arrhythmias (incl. torsade de pointes), myocardial infarction, intestinal ischaemia, skin and injection-site necrosis, uterine hypertonus/ischaemia.International label, same product · medicines.ie (Ferring Ireland Limited / HPRA)

• Hypersensitivity to terlipressin or excipients; pregnancy.International label, same product · medicines.ie (Ferring Ireland Limited / HPRA)

• Hepatorenal syndrome: confirm acute functional renal failure unresponsive to plasma expansion; fatal respiratory failure (incl. fluid overload) reported - stabilise breathing before first dose and consider reducing albumin; sepsis/septic shock reported - monitor daily for infection.International label, same product · medicines.ie (Ferring Ireland Limited / HPRA)
• May induce ischaemia and pulmonary vascular congestion: caution in cardiovascular or pulmonary disease, hypertension, renal dysfunction, cerebral or peripheral vascular disease, asthma; do not use in septic shock with low cardiac output. Skin necrosis unrelated to injection site reported (diabetes/obesity at higher risk). QT prolongation and torsade de pointes reported - extreme caution with QT history, electrolyte disturbances or QT-prolonging drugs.International label, same product · medicines.ie (Ferring Ireland Limited / HPRA)
• Contains 1.33 mmol (30.7 mg) sodium per ampoule.International label, same product · medicines.ie (Ferring Ireland Limited / HPRA)

• Non-selective beta-blockersHypotensive effect on the portal vein is increased with terlipressin.medicines.ie (Ferring Ireland Limited / HPRA)
• Bradycardic drugs (e.g. propofol, sufentanil)May lower heart rate and cardiac output.medicines.ie (Ferring Ireland Limited / HPRA)
• QT-prolonging drugs (class IA/III antiarrhythmics, erythromycin, certain antihistamines, tricyclic antidepressants) and drugs causing hypokalaemia/hypomagnesaemiaIncreased risk of torsade de pointes; extreme caution.medicines.ie (Ferring Ireland Limited / HPRA)

• Contraindicated in pregnancy: causes uterine contractions and increased intrauterine pressure in early pregnancy and may decrease uterine blood flow; spontaneous abortion and malformations seen in rabbits.International label, same product · medicines.ie (Ferring Ireland Limited / HPRA)
• Unknown whether excreted in human milk; risk to the suckling child cannot be excluded - weigh benefit of breastfeeding against benefit of therapy.International label, same product · medicines.ie (Ferring Ireland Limited / HPRA)

• Terlipressin acetate: Pro-drug with partial intrinsic activity, enzymatically converted to lysine-vasopressin; reduces portal venous pressure and causes marked vasoconstriction (effect lasting 4-6 hours).