سعر مينيرين 4مكجم/مل 10 امبول عضل وريد تحت الجلد حقن 2022

Desmopressin acetate 4 micrograms/ml solution for injection (Minirin; Ferring Pharmaceuticals, marketed by Multipharma), 10 ampoules, for i.m./i.v./s.c. use.

• Antidiuretic replacement therapy in central (cranial) diabetes insipidus and temporary polyuria/polydipsia after head trauma or pituitary surgery.Population: Adults and children aged 12 years and olderDailyMed (U.S. NLM)
• Haemophilia A with factor VIII coagulant activity above 5% (without factor VIII antibodies): haemostasis during and after surgery and for spontaneous or traumatic bleeding.Population: Adults and children aged 3 months and olderDailyMed (U.S. NLM)
• Mild to moderate von Willebrand disease type I with factor VIII levels above 5% (not severe type I).Population: Adults and children aged 3 months and olderDailyMed (U.S. NLM)

• Common adverse reactions include abdominal cramps, burning pain, erythema and swelling at the injection site, facial flushing, headache and nausea; hyponatraemia, hypertension/hypotension and thrombotic events have been reported.International label, same formulation · DailyMed (U.S. NLM)

• Hypersensitivity to desmopressin acetate or any component.International label, same formulation · DailyMed (U.S. NLM)
• Increased risk of hyponatraemia: creatinine clearance below 50 mL/min, hyponatraemia or history of it, known or suspected SIADH, polydipsia, concomitant loop diuretics or systemic/inhaled glucocorticoids, and illnesses causing fluid/electrolyte imbalance.International label, same formulation · DailyMed (U.S. NLM)
• Conditions worsened by fluid retention, including heart failure and uncontrolled hypertension.International label, same formulation · DailyMed (U.S. NLM)

• Boxed warning: can cause hyponatraemia, which may be life-threatening (seizures, coma, respiratory arrest, death); ensure serum sodium is normal before starting or resuming, restrict free water and monitor sodium.International label, same formulation · DailyMed (U.S. NLM)
• May cause hypotension (with reflex tachycardia) or hypertension; monitor blood pressure, especially with coronary insufficiency or hypertensive cardiovascular disease.International label, same formulation · DailyMed (U.S. NLM)
• In von Willebrand disease type IIB it may cause platelet aggregation, thrombocytopenia and possibly thrombosis. Hypersensitivity reactions including fatal anaphylaxis have been reported with IV use.International label, same formulation · DailyMed (U.S. NLM)

• Tricyclic antidepressants, SSRIs, chlorpromazine, opiate analgesics, thiazide diuretics, NSAIDs, lamotrigine, sulfonylureas (especially chlorpropamide), oxybutynin, carbamazepineIncrease the risk of hyponatraemia; monitor serum sodium more frequently.DailyMed (U.S. NLM)
• Loop diuretics; systemic or inhaled glucocorticoidsConcomitant use is contraindicated (increased risk of severe hyponatraemia).DailyMed (U.S. NLM)
• Other vasoconstrictorsMay raise blood pressure; the desmopressin dose may need reduction.DailyMed (U.S. NLM)

• Decades of use in pregnancy have not identified a drug-associated risk of major birth defects, miscarriage or adverse outcomes; placental transfer is poor.International label, same formulation · DailyMed (U.S. NLM)
• Transfer into breast milk is negligible; breastfeeding is not expected to cause clinically relevant infant exposure.International label, same formulation · DailyMed (U.S. NLM)

• Desmopressin acetate: Synthetic analogue of arginine vasopressin with strong V2 antidiuretic activity (increases renal water reabsorption).