سعر جرافالون 20 مجم/مل فيال 5 مل 2026

Anti-human T-lymphocyte immunoglobulin from rabbits 20 mg/mL concentrate for infusion, 5 mL vial (Grafalon; Fresenius Biotech GmbH, imported by Egyptian Group for Import and Export).

• Prevention of acute transplant rejection in allogeneic solid organ transplantation, in combination with other immunosuppressants.Population: Transplant recipientsHealth Products Regulatory Authority (HPRA), Ireland
• Therapy of acute corticosteroid-resistant rejection after allogeneic solid organ transplantation when methylprednisolone has been unsatisfactory.Population: Transplant recipientsHealth Products Regulatory Authority (HPRA), Ireland

• Ireland: infections, cytokine release related symptoms (fever, chills, headache, nausea, vomiting, tachycardia, circulatory changes), hypersensitivity including anaphylaxis, thrombocytopenia, leukopenia and pancytopenia; serum sickness with long treatment.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland

• Ireland: hypersensitivity; bacterial, viral, mycotic or parasitic infections not under adequate control; severe thrombocytopenia (<50,000 platelets/microlitre) in solid organ transplant patients; malignant tumours except when stem cell transplantation is part of treatment.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland

• Ireland: monitor closely for hypersensitivity/anaphylaxis; increased anaphylaxis risk on re-exposure to Grafalon or other rabbit immunoglobulins; cytokine release reactions may occur.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland
• Ireland: may enhance thrombocytopenia (monitor platelets and coagulation); live attenuated vaccines are contraindicated in immunosuppressed patients; monitor CMV/EBV status in stem cell transplantation.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland

• Live attenuated vaccinesIreland: contraindicated in immunosuppressed patients; antibody response to other vaccines may be reduced.Health Products Regulatory Authority (HPRA), Ireland
• Other immunosuppressantsIreland: co-administration may increase the risk of infection, thrombocytopenia and anaemia.Health Products Regulatory Authority (HPRA), Ireland

• Ireland: no clinical or animal data on exposed pregnancies; potential fetal risk unknown; caution in pregnant women and a risk/benefit decision by the treating physician.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland
• Ireland: human immunoglobulin may be excreted into breast milk; treatment of lactating women is a risk/benefit decision.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland

• Anti-human T-lymphocyte immunoglobulin (rabbit): Polyclonal rabbit antibodies against human T-lymphoblasts (Jurkat line) that bind T lymphocytes and cause T-cell depletion.