سعر جراندوكالن 4 مجم 10 أقراص 2022

Fesoterodine 4 mg extended-release tablets (Delta Grand Pharma), 10 tablets per pack.

• Overactive bladder with symptoms of urge urinary incontinence, urgency and frequency in adults.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Neurogenic detrusor overactivity in paediatric patients aged 6 years and older weighing more than 25 kg.Population: Children ≥6 years, >25 kgDailyMed (U.S. National Library of Medicine)

• US adults: dry mouth (19% at 4 mg, 35% at 8 mg vs 7% placebo) and constipation (4% and 6% vs 2% placebo) were the most common adverse reactions.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• US: urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, and hypersensitivity to fesoterodine, tolterodine or any ingredient.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• US: angioedema of the face, lips, tongue or larynx has been reported; risk of urinary retention in bladder outlet obstruction; use with caution in decreased GI motility, controlled narrow-angle glaucoma and myasthenia gravis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• US: CNS anticholinergic effects (e.g. dizziness, somnolence) may occur; patients should not drive or operate machinery until they know how the drug affects them.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, itraconazole)US: ketoconazole about doubled exposure to the active metabolite 5-HMT; adult dose should not exceed 4 mg daily.DailyMed (U.S. National Library of Medicine)
• Other antimuscarinic agentsUS: concomitant use may increase the frequency and severity of anticholinergic effects (dry mouth, constipation, urinary retention).DailyMed (U.S. National Library of Medicine)

• US: no available human data on fesoterodine in pregnancy; fetotoxicity was observed in animal studies at exposures above clinical exposure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• US: no information on the presence of fesoterodine in human milk or effects on the breastfed infant.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fesoterodine: Competitive muscarinic receptor antagonist; rapidly hydrolysed by nonspecific esterases to its active metabolite 5-hydroxymethyl tolterodine.