سعر افيونول 4 مجم 10 اقراص 2022

Fesoterodine 4 mg extended-release tablets, 10 tablets; antimuscarinic for overactive bladder (Marcyrl Co. > ECCO Pharm, Egypt).

• Treatment of overactive bladder (OAB) in adults with symptoms of urge urinary incontinence, urgency and frequency.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Treatment of neurogenic detrusor overactivity (NDO) in pediatric patients 6 years of age and older with body weight greater than 25 kg.Population: Children 6 years and older, >25 kgDailyMed (U.S. National Library of Medicine)

• Adults (12-week trials): dry mouth was most common (about 19% with 4 mg and 35% with 8 mg vs 7% placebo), followed by constipation (4% and 6% vs 2%); other reactions included dyspepsia, urinary tract infection, dry eyes and urinary retention/dysuria.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Children with NDO: diarrhoea, urinary tract infection, dry mouth, constipation, abdominal pain, nausea, weight increase and headache; ophthalmological reactions and dose-related increases in heart rate were also reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Postmarketing: palpitations, dizziness, headache, somnolence, blurred vision, oral hypoaesthesia, hypersensitivity including angioedema, confusional state, urticaria and pruritus.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known or suspected hypersensitivity to fesoterodine or any ingredient, or to tolterodine tartrate (reactions have included angioedema).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Urinary retention.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Gastric retention.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Angioedema of the face, lips, tongue and/or larynx has been reported, sometimes after the first dose; discontinue promptly and secure the airway if the tongue, hypopharynx or larynx is involved.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Not recommended in clinically significant bladder outlet obstruction (risk of urinary retention and kidney injury).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Decreases gastrointestinal motility; not recommended in decreased GI motility such as severe constipation.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Other antimuscarinic agentsMay increase the frequency and/or severity of dry mouth, constipation, urinary retention and other anticholinergic effects.DailyMed (U.S. National Library of Medicine)
• Strong CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, clarithromycin)Ketoconazole about doubled Cmax and AUC of the active metabolite; doses above 4 mg are not recommended in adults.DailyMed (U.S. National Library of Medicine)
• CYP3A4 inducers (e.g. rifampin, carbamazepine)Rifampin decreased Cmax and AUC of the active metabolite by about 70% and 75%; no dose adjustment is recommended.DailyMed (U.S. National Library of Medicine)

• No available human data to evaluate drug-associated risk; in animal studies oral fesoterodine during organogenesis caused fetotoxicity at maternal exposures 6 (mice) and 3 (rabbits) times the maximum recommended human dose, with no dose-related teratogenicity.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on presence in human milk, effects on the breastfed child or on milk production; weigh the benefits of breastfeeding against the mother's clinical need and potential adverse effects on the infant.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fesoterodine: Competitive muscarinic receptor antagonist; rapidly and extensively hydrolysed by nonspecific esterases to its active metabolite 5-hydroxymethyl tolterodine, which inhibits bladder muscarinic receptors involved in detrusor contraction.