سعر هيدريا 500مجم 20 كبسولة 2023

Hydroxyurea 500 mg capsules, an oral antimetabolite (ribonucleotide reductase inhibitor) used in some cancers.

• Resistant chronic myeloid leukaemia.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Locally advanced squamous cell carcinoma of the head and neck (excluding the lip), in combination with chemoradiation.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Postmarketing: stomatitis, nausea, vomiting, diarrhoea, constipation, anorexia, rash, skin ulceration, hyperpigmentation, alopecia, raised BUN/creatinine/uric acid, headache, dizziness, fever, raised liver enzymes, pulmonary infiltrates/fibrosis, azoospermia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Previous hypersensitivity to hydroxyurea or any component of the formulation.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Severe myelosuppression (leukopenia first, then thrombocytopenia/anaemia); do not start if marrow function is markedly depressed; correct severe anaemia before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Human carcinogen: secondary leukaemia and skin cancer reported with long-term use; advise sun protection.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Cutaneous vasculitic ulceration/gangrene (mainly with interferon history), haemolytic anaemia, radiation recall, macrocytosis and interstitial lung disease reported; avoid live vaccines.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Didanosine, stavudine (antiretrovirals)Fatal and non-fatal pancreatitis, hepatotoxicity/hepatic failure and peripheral neuropathy reported in HIV patients; avoid the combination.DailyMed (U.S. National Library of Medicine)
• Live vaccinesMay potentiate vaccine virus replication and cause severe infection; antibody response may be reduced.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm (embryotoxic and teratogenic in animals at below human doses); no human pregnancy data. Avoid pregnancy during treatment; verify pregnancy status before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hydroxyurea is excreted in human milk; discontinue breastfeeding during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hydroxyurea: Inhibits ribonucleotide reductase, depleting deoxyribonucleotides and impairing DNA synthesis (S-phase specific).