سعر هيدروكسوكوبالامين 1500 مكجم 3 امبولات 2022

Hydroxocobalamin 1500 mcg solution for intramuscular injection (Hydroxocobalamin, Pharco B, Egypt); pack of 3 ampoules.

• Frequency not known: reactive thrombocytosis, hypersensitivity (rash, itching, exanthema, anaphylaxis), antibodies to the hydroxocobalamin-transcobalamin II complex, initial hypokalaemia, headache, paraesthesia, tremor, arrhythmias secondary to hypokalaemia, nausea, vomiting, diarrhoea, fever, chills, hot flushes, dizziness, malaise, injection-site reactions, acneiform and bullous eruptions, chromaturia.General active-ingredient information · electronic medicines compendium (emc)

• Hypersensitivity to hydroxocobalamin or to any of the excipients.General active-ingredient information · electronic medicines compendium (emc)

• Confirm the diagnosis of vitamin B12 deficiency before treatment; if megaloblastic anaemia fails to respond, investigate folate metabolism; doses above 10 mcg daily may produce a haematological response in folate deficiency and indiscriminate use may mask the true diagnosis.General active-ingredient information · electronic medicines compendium (emc)
• Cardiac arrhythmias secondary to hypokalaemia have been reported during initial therapy.General active-ingredient information · electronic medicines compendium (emc)
• Folic acid is not a substitute for vitamin B12; exclusive folic acid treatment of B12-deficient megaloblastic anaemia may cause progressive, irreversible neurological damage. Response may be blunted by infection, uraemia, marrow-suppressant drugs (e.g. chloramphenicol) or concurrent iron or folate deficiency; B12 deficiency may mask polycythaemia vera.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Chloramphenicol (parenteral)May attenuate the effect of hydroxocobalamin in anaemia (unlikely to be clinically significant but relevant to blood assays).electronic medicines compendium (emc)
• Oral contraceptivesSerum hydroxocobalamin concentrations may be lowered.electronic medicines compendium (emc)
• Antimetabolites and most antibioticsInvalidate vitamin B12 assays by microbiological techniques.electronic medicines compendium (emc)

• Hydroxocobalamin injection should not be used for the treatment of megaloblastic anaemia of pregnancy.General active-ingredient information · electronic medicines compendium (emc)
• No animal reproduction studies; give to a pregnant woman only if clearly needed.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Hydroxocobalamin is secreted into breast milk but is unlikely to harm the infant.General active-ingredient information · electronic medicines compendium (emc)

• Regular monitoring of the blood is recommended; monitor plasma potassium during initial therapy.General active-ingredient information · electronic medicines compendium (emc)
• Monitor serum potassium closely during the first 48 hours and the platelet count during therapy; follow haematological response (haemoglobin, haematocrit, red cells, reticulocytes).General active-ingredient information · DailyMed (U.S. National Library of Medicine)

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