سعر ايمبلاتينز 500/500 مجم فيال محلول وريدي 2024

Imipenem 500 mg + cilastatin 500 mg vial for intravenous infusion (1 vial), Pharco B International, Egypt; carbapenem antibacterial.

• Serious infections caused by susceptible bacteria: lower respiratory tract, urinary tract (complicated and uncomplicated), intra-abdominal, gynaecologic, bacterial septicaemia, bone and joint, skin and skin-structure infections and endocarditisDailyMed (U.S. National Library of Medicine)

• Most frequent in adults: phlebitis/thrombophlebitis (3.1%), nausea (2%), diarrhoea (1.8%), vomiting (1.5%), rash (0.9%), injection-site pain (0.7%), fever (0.5%), hypotension (0.4%) and seizures (0.4%).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any component of the product.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serious, occasionally fatal hypersensitivity (anaphylactic) reactions occur with beta-lactams; ask about prior penicillin, cephalosporin or other beta-lactam allergy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Seizures and other CNS effects (confusion, myoclonus) can occur, especially when recommended doses are exceeded or with CNS disorders or renal impairment; co-administration with valproic acid/divalproex lowers valproate levels and is generally not recommended.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea may occur; prolonged use may cause overgrowth of non-susceptible organisms. Not indicated for meningitis. Periodically assess renal, hepatic and haematopoietic function during prolonged therapy.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• GanciclovirGeneralised seizures reported; do not use together unless benefits outweigh risks.DailyMed (U.S. National Library of Medicine)
• ProbenecidIncreases imipenem plasma levels and half-life; concomitant use not recommended.DailyMed (U.S. National Library of Medicine)
• Valproic acid / divalproex sodiumCarbapenems reduce valproic acid concentrations, risking breakthrough seizures; generally not recommended, consider other antibacterials or supplemental anticonvulsant therapy.DailyMed (U.S. National Library of Medicine)

• Available data from a small number of post-marketing cases are insufficient to identify drug-associated risks of major birth defects, miscarriage or adverse outcomes; animal studies showed no embryo-fetal effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Insufficient data on presence in human milk and no data on effects on the breastfed child or milk production; weigh benefits of breastfeeding against maternal need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

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