سعر ايسوبتن ريتارد 240 مجم 20 قرص 2022

Isoptin Retard verapamil hydrochloride 240 mg sustained-release film-coated tablets (pack of 20), a phenylalkylamine calcium channel blocker for hypertension.

• Treatment of hypertension to lower blood pressure (reduces risk of fatal and nonfatal cardiovascular events).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>1%): constipation, dizziness, nausea, hypotension, headache, edema, CHF/pulmonary edema, fatigue, dyspnea, bradycardia, AV block, rash, flushing; elevated liver enzymes.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Severe left ventricular dysfunction; hypotension (SBP <90 mmHg) or cardiogenic shock; sick sinus syndrome (unless paced); second- or third-degree AV block (unless paced); atrial flutter/fibrillation with accessory bypass tract (e.g. WPW); known hypersensitivity to verapamil.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Heart failure: avoid in severe LV dysfunction or if on a beta-blocker with any ventricular dysfunction. Hypotension may occur. Elevated liver enzymes and hepatocellular injury reported.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• CYP3A4 inhibitors (e.g. erythromycin, ritonavir) / inducers (e.g. rifampin)Inhibitors raise and inducers lower verapamil plasma levels.DailyMed (U.S. National Library of Medicine)
• Simvastatin / lovastatin (CYP3A4 substrate HMG-CoA reductase inhibitors)Increased myopathy/rhabdomyolysis risk; limit simvastatin to 10 mg daily and lovastatin to 40 mg with verapamil.DailyMed (U.S. National Library of Medicine)
• DigoxinChronic verapamil can increase serum digoxin 50–75% in the first week; adjust digoxin dose and monitor.DailyMed (U.S. National Library of Medicine)

• Animal studies at high multiples of human dose showed no teratogenicity but embryocidal effects/retarded fetal growth in rats; no adequate human studies; use only if clearly needed. Verapamil crosses the placenta.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Verapamil is excreted in human milk; nursing should be discontinued while verapamil is administered.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Verapamil: Blocks L-type calcium channels in vascular smooth muscle and myocardium, reducing peripheral resistance and blood pressure.