سعر جانوميت 50/500 مجم 56 قرص مغلف 2024

Janumet 50/500 mg 56 film-coated tablets: sitagliptin 50 mg + metformin HCl 500 mg film-coated tablets, 56-tablet pack (Patheon-Puerto Rico > Soficopharm).

• Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes when treatment with both sitagliptin and metformin is appropriate.Population: Adults with type 2 diabetesDailyMed (U.S. National Library of Medicine)

• Common: diarrhea, upper respiratory infection, headache; metformin GI effects.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Severe renal impairment, metabolic acidosis including diabetic ketoacidosis; hypersensitivity to sitagliptin or metformin.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Lactic acidosis (metformin boxed warning); pancreatitis; vitamin B12 deficiency; heart failure; hypoglycemia with insulin/SU; discontinue for iodinated contrast when eGFR restricted.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Use in pregnancy only if clearly needed per US labeling; poorly controlled diabetes in pregnancy carries risks. Discuss breastfeeding with the label/pharmacist.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Sitagliptin: DPP-4 inhibitor prolonging incretin activity.
• Metformin: Decreases hepatic glucose production, decreases intestinal glucose absorption and improves insulin sensitivity by increasing peripheral glucose uptake and utilization; insulin secretion remains unchanged (US label).