سعر Andoglycemic XR 1000 mg 30 extended-release tablets 2026

Extended-release tablets containing metformin hydrochloride 1000 mg (Al Andalous Pharmaceutical Industries), a biguanide oral antidiabetic; 30 tablets per pack.

• Adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitusPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>5%): hypoglycaemia, diarrhoea and nausea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Severe renal impairment (eGFR <30 mL/min/1.73 m2).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to metformin.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning - lactic acidosis: post-marketing cases, some fatal; risk factors include renal impairment, concomitant drugs (e.g., carbonic anhydrase inhibitors), age 65 or older, radiological studies with contrast, surgery, hypoxic states, excessive alcohol and hepatic impairment. Discontinue immediately if suspected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Discontinue at the time of or before iodinated contrast imaging in patients with eGFR 30-60, liver disease, alcoholism or heart failure, and in intra-arterial contrast; re-evaluate eGFR 48 hours after; withhold during surgery with restricted food/fluid intake.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Vitamin B12 deficiency may occur; measure haematological parameters annually and B12 every 2-3 years.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Carbonic anhydrase inhibitors (e.g., topiramate, zonisamide, acetazolamide, dichlorphenamide)Increased risk of lactic acidosis; consider more frequent monitoring.DailyMed (U.S. National Library of Medicine)
• Drugs that reduce metformin clearance (ranolazine, vandetanib, dolutegravir, cimetidine)Increased metformin exposure and lactic acidosis risk; consider benefit-risk.DailyMed (U.S. National Library of Medicine)
• AlcoholPotentiates the effect of metformin on lactate metabolism; warn against excessive intake.DailyMed (U.S. National Library of Medicine)

• Limited published data with metformin in pregnancy have not reported a clear drug-associated risk of major birth defects or miscarriage; poorly controlled diabetes in pregnancy carries maternal and fetal risks.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Metformin hydrochloride: Decreases hepatic glucose production, decreases intestinal glucose absorption and improves insulin sensitivity by increasing peripheral glucose uptake and utilization; insulin secretion remains unchanged (US label).