سعر كلاسيد 500مجم فيال 2024

Clarithromycin 500 mg powder for intravenous infusion, 1 vial (Klacid, Abbott Laboratories); macrolide antibacterial for parenteral use.

• Lower and upper respiratory tract infections and skin and soft tissue infections requiring parenteral therapy (Irish SmPC).Population: Adults and children 12 years and oldermedicines.ie (Irish Pharmaceutical Healthcare Association) / HPRA-authorised SmPC

• Most common: abdominal pain, diarrhoea, nausea, vomiting and taste perversion; with the intravenous form injection site phlebitis is common and injection site pain and inflammation also occur.International label, same formulation · medicines.ie (Irish Pharmaceutical Healthcare Association) / HPRA-authorised SmPC

• Hypersensitivity to macrolides or excipients; concomitant astemizole, cisapride, domperidone, pimozide, terfenadine, ticagrelor, ivabradine, ranolazine, ergot alkaloids, lomitapide, lovastatin, simvastatin, colchicine or oral midazolam.International label, same formulation · medicines.ie (Irish Pharmaceutical Healthcare Association) / HPRA-authorised SmPC
• History of QT prolongation or ventricular arrhythmia, hypokalaemia or hypomagnesaemia, and severe hepatic failure combined with renal impairment.International label, same formulation · medicines.ie (Irish Pharmaceutical Healthcare Association) / HPRA-authorised SmPC

• Hepatic dysfunction including hepatitis and, rarely, fatal hepatic failure; stop treatment if signs of hepatitis appear; caution in hepatic and moderate to severe renal impairment.International label, same formulation · medicines.ie (Irish Pharmaceutical Healthcare Association) / HPRA-authorised SmPC
• QT prolongation and arrhythmia risk; caution in coronary artery disease, severe cardiac insufficiency, conduction disturbances, bradycardia and with other QT-prolonging drugs. Clostridioides difficile-associated diarrhoea may occur.International label, same formulation · medicines.ie (Irish Pharmaceutical Healthcare Association) / HPRA-authorised SmPC

• ColchicineContraindicated (colchicine toxicity, deaths reported, especially in the elderly and in renal insufficiency).medicines.ie (Irish Pharmaceutical Healthcare Association) / HPRA-authorised SmPC
• CYP3A4-metabolised statins (lovastatin, simvastatin)Contraindicated because of increased risk of myopathy including rhabdomyolysis.medicines.ie (Irish Pharmaceutical Healthcare Association) / HPRA-authorised SmPC
• Triazolobenzodiazepines (triazolam) and intravenous or oromucosal midazolamIncreased sedative exposure; use with caution (oral midazolam is contraindicated).medicines.ie (Irish Pharmaceutical Healthcare Association) / HPRA-authorised SmPC

• Safety in pregnancy has not been established; adverse effects on embryofoetal development cannot be excluded, some observational studies reported an increased risk of miscarriage with first- and second-trimester exposure; use only after carefully weighing benefits against risks.International label, same formulation · medicines.ie (Irish Pharmaceutical Healthcare Association) / HPRA-authorised SmPC
• Excreted into human milk in small amounts; an exclusively breastfed infant would receive about 1.7% of the maternal weight-adjusted dose; safety in breastfed infants not established.International label, same formulation · medicines.ie (Irish Pharmaceutical Healthcare Association) / HPRA-authorised SmPC

• Clarithromycin: Binds the 50S subunit of the bacterial ribosome and inhibits bacterial protein synthesis.