سعر ليسكول 80مجم اكس ال 28 قرص 2022

Lescol XL fluvastatin 80 mg extended-release film-coated tablets, pack of 28 (Novartis); HMG-CoA reductase inhibitor.

• To reduce the risk of coronary revascularization procedures and slow progression of coronary atherosclerosis in adults with clinically evident coronary heart disease.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Adjunct to diet to reduce LDL-C in adults with primary hyperlipidaemia.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Adjunct to diet to reduce LDL-C in heterozygous familial hypercholesterolaemia in patients who require 80 mg of fluvastatin daily.Population: Adults and paediatric patients 10 years and olderDailyMed (U.S. National Library of Medicine)

• Most frequent (≥2.5% and more than placebo): influenza-like symptoms, sinusitis, dyspepsia, urinary tract infection, bronchitis and nausea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Acute liver failure or decompensated cirrhosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to fluvastatin or any excipient (anaphylaxis, angioedema and Stevens-Johnson syndrome reported).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis: risk factors include age 65 or older, uncontrolled hypothyroidism, renal impairment and certain concomitant drugs; discontinue if CK is markedly elevated or myopathy is suspected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Immune-mediated necrotizing myopathy has rarely been reported with statins; discontinue if suspected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic dysfunction: transaminase increases and rare hepatic failure; consider liver enzyme tests before starting and as clinically indicated.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Gemfibrozil; cyclosporine; fluconazoleAvoid concomitant use (increased risk of myopathy/rhabdomyolysis).DailyMed (U.S. National Library of Medicine)
• Fibrates, niacin ≥1 g/day, colchicineConsider whether benefit outweighs increased myopathy risk; monitor for myopathy.DailyMed (U.S. National Library of Medicine)
• WarfarinObtain INR before starting and frequently after starting or stopping fluvastatin.DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognised, or consider the ongoing therapeutic needs of the patient; statins may cause fetal harm based on mechanism, and treatment of hyperlipidaemia is generally not necessary during pregnancy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on presence in human milk; breastfeeding is not recommended during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fluvastatin: Competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme converting HMG-CoA to mevalonate, a cholesterol precursor (US LESCOL XL label).