سعر لوكيران 2مجم 25 قرص 2024

Leukeran chlorambucil 2 mg film-coated tablets, pack of 25 (Aspen); nitrogen-mustard alkylating antineoplastic.

• Chronic lymphatic (lymphocytic) leukaemia and malignant lymphomas including lymphosarcoma, giant follicular lymphoma and Hodgkin's disease; palliative, not curative.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common: bone marrow suppression (anaemia, leukopenia, neutropenia, thrombocytopenia, pancytopenia), usually reversible if stopped early, though irreversible marrow failure has been reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Infrequent nausea, vomiting, diarrhoea and oral ulceration; rare CNS effects (tremor, myoclonia, confusion, hallucinations); other: pulmonary fibrosis, hepatotoxicity and jaundice, drug fever, peripheral neuropathy, interstitial pneumonia, sterile cystitis, infertility.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Disease that has demonstrated prior resistance to chlorambucil.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to chlorambucil; cross-hypersensitivity (skin rash) with other alkylating agents may occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: can severely suppress bone marrow function; carcinogenic in humans; probably mutagenic and teratogenic; produces human infertility.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Because of carcinogenic properties, should not be used for conditions other than CLL or malignant lymphomas; acute leukaemia and secondary malignancies have been reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Seizures have been reported in children and adults at therapeutic and pulse doses and in overdose; skin rash may progress to erythema multiforme, TEN or Stevens-Johnson syndrome.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Other medicinesThe US label states there are no known drug-drug interactions with chlorambucil.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm; unilateral renal agenesis reported in two offspring after first-trimester exposure; women of childbearing potential should avoid pregnancy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Not known whether excreted in human milk; because of potential serious adverse reactions, decide whether to discontinue nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Chlorambucil: Aromatic nitrogen mustard alkylating agent; interferes with DNA replication and induces apoptosis via accumulation of cytosolic p53 and activation of Bax (US label).