سعر لوكاستن قرص مهبلي واحد 2022

Locasten single vaginal tablet (Alexandria): clotrimazole imidazole antifungal, 1 vaginal tablet; the strength is listed inconsistently (1500 mg vs "1 500 mg").

• Frequency not known (spontaneous reports): anaphylactic reaction, angioedema, hypersensitivity, syncope, hypotension, dyspnoea, abdominal pain, nausea, rash, urticaria, pruritus, vaginal exfoliation, discharge or haemorrhage, vulvovaginal discomfort, erythema, burning, pruritus or pain, and application-site irritation, oedema or pain.General active-ingredient information · UK electronic Medicines Compendium (medicines.org.uk)

• Hypersensitivity to clotrimazole or to any of the excipients.General active-ingredient information · UK electronic Medicines Compendium (medicines.org.uk)

• Seek medical advice if this is the first episode of candidal vaginitis, or before use if: more than two infections in the last 6 months, previous sexually transmitted disease or exposure to a partner with one, pregnancy or suspected pregnancy, age under 16 or over 60, or known hypersensitivity to imidazoles or other vaginal antifungals.General active-ingredient information · UK electronic Medicines Compendium (medicines.org.uk)
• Do not use and seek medical advice if there is irregular or abnormal vaginal bleeding or blood-stained discharge, vulval or vaginal ulcers, blisters or sores, lower abdominal pain or dysuria, redness/irritation/swelling with treatment, fever or chills, nausea or vomiting, diarrhoea, or foul-smelling discharge. Do not treat during menstruation; do not use tampons, douches, spermicides or other vaginal products; avoid vaginal intercourse during infection and treatment; consult a physician if symptoms are not relieved within one week.General active-ingredient information · UK electronic Medicines Compendium (medicines.org.uk)

• Latex contraceptives (condoms, diaphragms)May damage latex contraceptives, reducing their effectiveness; use alternative precautions for at least 5 days after treatment.UK electronic Medicines Compendium (medicines.org.uk)
• Tacrolimus / sirolimus (oral)Concomitant vaginal clotrimazole may increase tacrolimus or sirolimus plasma levels; monitor for overdose signs and check levels if necessary.UK electronic Medicines Compendium (medicines.org.uk)

• Limited human data and harmful reproductive effects are not predicted at the low systemic exposure after vaginal use; clotrimazole may be used in pregnancy only under the supervision of a physician or midwife; during pregnancy the pessary should be inserted without an applicator.General active-ingredient information · UK electronic Medicines Compendium (medicines.org.uk)
• No data on excretion into human milk, but systemic absorption is minimal; clotrimazole may be used during lactation.General active-ingredient information · UK electronic Medicines Compendium (medicines.org.uk)

• Clotrimazole: Inhibits ergosterol synthesis in the fungal cell membrane, increasing membrane permeability and causing cell death.