سعر لوكيلما 10جم 3 اكياس 2024

Lokelma (AstraZeneca) sodium zirconium cyclosilicate 10 g powder for oral suspension, pack of 3 sachets: a non-absorbed potassium binder used to treat hyperkalaemia in adults.

• Treatment of hyperkalaemia in adults. Not for emergency treatment of life-threatening hyperkalaemia because of its delayed onset of action.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Oedema: 4.4% (5 g), 5.9% (10 g) and 16.1% (15 g) vs 2.4% placebo in up to 28-day trials; 8-11% in longer uncontrolled trials.International label, same product · DailyMed (U.S. National Library of Medicine)
• Hypokalaemia (serum potassium < 3.5 mEq/L) in 4.1% of non-dialysis patients, resolving with dose reduction or discontinuation; constipation reported in studies in predominantly Asian populations (about 9% at 10 g and 5% at 5 g).International label, same product · DailyMed (U.S. National Library of Medicine)

• None (US label).International label, same product · DailyMed (U.S. National Library of Medicine)

• Avoid in severe constipation, bowel obstruction or impaction, including abnormal post-operative bowel motility; not studied and may be ineffective or worsen gastrointestinal conditions.International label, same product · DailyMed (U.S. National Library of Medicine)
• Each 5 g dose contains about 400 mg sodium; oedema was seen (more often at 15 g daily). Monitor for oedema in patients who should restrict sodium or are prone to fluid overload (e.g. heart failure, renal disease); adjust dietary sodium or diuretics as needed.International label, same product · DailyMed (U.S. National Library of Medicine)
• Patients on haemodialysis may develop hypokalaemia during acute illness (e.g. reduced oral intake, diarrhoea); consider dose adjustment based on potassium.International label, same product · DailyMed (U.S. National Library of Medicine)

• Oral drugs with pH-dependent solubilityLokelma can transiently increase gastric pH and may change absorption of co-administered drugs with pH-dependent solubility; in general give other oral medicines at least 2 hours before or after Lokelma (spacing not needed for drugs shown not to have pH-dependent solubility).DailyMed (U.S. National Library of Medicine)

• Not absorbed systemically after oral use; maternal use is not expected to result in fetal exposure.International label, same product · DailyMed (U.S. National Library of Medicine)
• Not absorbed systemically; breastfeeding is not expected to expose the child to the drug.International label, same product · DailyMed (U.S. National Library of Medicine)

• Sodium zirconium cyclosilicate: Non-absorbed zirconium silicate that preferentially captures potassium in exchange for hydrogen and sodium in the gastrointestinal lumen, increasing faecal potassium excretion and lowering serum potassium.