سعر لوبرانيست 2مجم 20 فيلم 2024

Loperamide hydrochloride 2 mg orodispersible films, 20 films (Nerhadou International Co.).

• Symptomatic treatment of acute diarrhoea and of acute episodes of diarrhoea associated with irritable bowel syndrome diagnosed by a doctor.Population: Adults and children 12 years and over (IBS: adults 18 years and over)electronic medicines compendium (emc)

• Common: constipation (2.7%), flatulence (1.7%), headache (1.2%) and nausea (1.1%) in acute diarrhoea trials.International label, equivalent formulation · electronic medicines compendium (emc)

• Children less than 12 years of age; hypersensitivity to loperamide or any excipient.International label, equivalent formulation · electronic medicines compendium (emc)
• Acute dysentery (blood in stools and high fever); acute ulcerative colitis; bacterial enterocolitis caused by invasive organisms (Salmonella, Shigella, Campylobacter); pseudomembranous colitis associated with broad-spectrum antibiotics; when inhibition of peristalsis is to be avoided (risk of ileus, megacolon, toxic megacolon).International label, equivalent formulation · electronic medicines compendium (emc)

• Discontinue promptly if ileus, constipation or abdominal distension develop. Cardiac events including QT prolongation and torsades de pointes have been reported with overdose; do not exceed the recommended dose.International label, equivalent formulation · electronic medicines compendium (emc)

• P-glycoprotein inhibitors (e.g., quinidine, ritonavir)Increased loperamide plasma levels 2- to 3-fold.electronic medicines compendium (emc)
• Itraconazole, gemfibrozil and ketoconazoleItraconazole increased loperamide plasma concentrations 3-4-fold, gemfibrozil about 2-fold, the itraconazole-gemfibrozil combination about 13-fold (4-fold peak), and ketoconazole 5-fold.electronic medicines compendium (emc)

• Safety in human pregnancy has not been established, although animal studies show no teratogenic or embryotoxic effects; not advisable in pregnancy, especially during the first trimester.International label, equivalent formulation · electronic medicines compendium (emc)
• Small amounts of loperamide may appear in human breast milk; not recommended during breast-feeding.International label, equivalent formulation · electronic medicines compendium (emc)

• Loperamide: Acts on opiate receptors in the gut wall, inhibiting peristalsis, prolonging transit time and reducing fecal volume (US label).