سعر لورافيدرين 5/240مجم 20 قرص 2025

Lorafedrine 5/240 mg by Marcyrl / Pharma Right Group (Egypt): extended-release tablets combining desloratadine (H1 antihistamine) and pseudoephedrine (nasal decongestant).

• In US trials of the 12-hour combination (desloratadine 2.5 mg/pseudoephedrine 120 mg twice daily) reactions in at least 2% were insomnia (10%), dry mouth (8%), headache (8%), fatigue (4%), somnolence (3%), dizziness (3%), pharyngitis (3%), nausea (2%) and anorexia (2%).General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Contraindicated in hypersensitivity to any ingredient or to loratadine; narrow-angle glaucoma; urinary retention; patients receiving MAO inhibitors or within 14 days of stopping them; severe hypertension or severe coronary artery disease.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Pseudoephedrine, like other sympathomimetic amines, can cause cardiovascular and CNS effects (insomnia, dizziness, weakness, tremor, arrhythmias; rarely convulsions or cardiovascular collapse); use with caution in cardiovascular disorders, diabetes, hyperthyroidism, prostatic hypertrophy or increased intraocular pressure.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity reactions (rash, pruritus, urticaria, oedema, dyspnoea, anaphylaxis) have been reported with desloratadine; stop treatment if they occur. The US combination label advises that it should generally be avoided in renal or hepatic impairment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Monoamine oxidase inhibitorsDo not use during or within 14 days of MAOI therapy: the vascular effect of pseudoephedrine may be potentiated (hypertensive crisis possible).DailyMed (U.S. National Library of Medicine)
• Beta-blockers, methyldopa, reserpineTheir antihypertensive effects may be reduced by sympathomimetics such as pseudoephedrine.DailyMed (U.S. National Library of Medicine)
• DigitalisIncreased ectopic pacemaker activity can occur with pseudoephedrine.DailyMed (U.S. National Library of Medicine)
• Ketoconazole, erythromycin, azithromycin, fluoxetine, cimetidineRaised desloratadine and 3-hydroxydesloratadine levels without clinically relevant changes in the safety profile in controlled studies.DailyMed (U.S. National Library of Medicine)

• Limited data with the combination in pregnant women are insufficient to inform a drug-associated risk; most studies of pseudoephedrine in pregnancy found no increased risk of congenital anomalies; desloratadine was not teratogenic in rats or rabbits at high exposures.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Desloratadine and pseudoephedrine pass into breast milk; pseudoephedrine may decrease milk production (24% reduction after a single 60 mg dose) and cause infant irritability. Decide whether to discontinue nursing or the drug.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Desloratadine: Long-acting tricyclic histamine antagonist with selective H1-receptor antagonist activity; the major active metabolite of loratadine.
• Pseudoephedrine: Sympathomimetic amine acting on alpha-adrenergic receptors in the respiratory mucosa to produce vasoconstriction and relieve nasal congestion.