سعر مانيتول 10% فيبكو محلول وريدي 500 مل 2022

Mannitol 10% w/v (10 g per 100 ml) solution for intravenous infusion in a 500 ml container, by El-Fath for the Industry of Medicine & Cosmetics (FIPCO), Egypt; an osmotic diuretic used to reduce intracranial and intraocular pressure.

• Reduction of intracranial pressure and treatment of cerebral edema.Population: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Reduction of elevated intraocular pressure.Population: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)

• Reported reactions include hypersensitivity reactions, acute kidney injury, CNS toxicity (seizures, confusion, dizziness), fluid and electrolyte imbalances, infusion-site reactions (phlebitis, pain, extravasation), congestive heart failure, pulmonary oedema, palpitations, thirst, dry mouth, asthenia and malaise.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to mannitol; anuria; severe hypovolaemia; pre-existing severe pulmonary vascular congestion or pulmonary oedema; active intracranial bleeding except during craniotomy.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serious hypersensitivity reactions, including anaphylaxis, hypotension and dyspnoea leading to cardiac arrest and death, have been reported; stop the infusion immediately if they occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Renal complications including irreversible renal failure and reversible oliguric acute kidney injury (osmotic nephrosis) can occur, even in patients with normal renal function given large doses.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• CNS toxicity (confusion, lethargy, coma) has been reported, particularly with impaired renal function; a rebound rise in intracranial pressure may occur several hours after the infusion.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Nephrotoxic drugs (e.g., ciclosporin, aminoglycosides)Increase the risk of renal failure with mannitol; avoid if possible.DailyMed (U.S. National Library of Medicine)
• Other diureticsMay potentiate the renal toxicity of mannitol; avoid if possible.DailyMed (U.S. National Library of Medicine)
• Neurotoxic drugs (e.g., aminoglycosides)May potentiate the CNS toxicity of mannitol; avoid if possible.DailyMed (U.S. National Library of Medicine)

• Decades of case-report data have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; mannitol crosses the placenta and may cause fetal fluid shifts.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• There are no data on mannitol in human or animal milk or its effects on the breastfed infant or milk production; weigh the benefits of breastfeeding against the mother's clinical need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Mannitol: Elevates the osmolarity of the glomerular filtrate, hindering tubular water reabsorption and increasing sodium and chloride excretion; the rise in extracellular osmolarity draws intracellular water into the extracellular and vascular spaces, which underlies its effect on intracranial and intraocular pressure.