سعر Mannitol 20% (otsuka) i.v. inf. 250 ml (rubber cap) 2026

Mannitol 20% solution for intravenous infusion, 250 ml bottle with rubber cap, by Otsuka (Egypt); osmotic diuretic.

• Reduction of intracranial pressure and treatment of cerebral oedema.DailyMed (U.S. National Library of Medicine)
• Reduction of elevated intraocular pressure.DailyMed (U.S. National Library of Medicine)

• Reported reactions include hypersensitivity reactions, acute kidney injury, CNS toxicity (seizures, confusion, dizziness), fluid and electrolyte imbalance, infusion-site reactions (phlebitis, extravasation with compartment syndrome) and heart failure or pulmonary oedema.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to mannitol; anuria; severe hypovolaemia; pre-existing severe pulmonary vascular congestion or pulmonary oedema; active intracranial bleeding except during craniotomy.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serious hypersensitivity reactions including anaphylaxis and cardiac arrest have been reported; stop the infusion immediately if they occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Renal complications including irreversible renal failure and osmotic nephrosis; avoid concomitant nephrotoxic drugs or other diuretics where possible.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• CNS toxicity (confusion, lethargy, coma) particularly with renal impairment; rebound increase in intracranial pressure may occur hours after infusion.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Nephrotoxic drugs (e.g. aminoglycosides) and other diureticsIncrease the risk of renal failure; avoid concomitant use if possible.DailyMed (U.S. National Library of Medicine)
• Drugs sensitive to electrolyte changes (digoxin, QT-prolonging agents, neuromuscular blockers)Mannitol-induced potassium changes may cause cardiac adverse reactions with these drugs.DailyMed (U.S. National Library of Medicine)
• Renally eliminated drugs (e.g. lithium)Mannitol may increase renal elimination and lower concentrations of such drugs.DailyMed (U.S. National Library of Medicine)

• Decades of case-report data have not identified a drug-associated risk of major birth defects or miscarriage; mannitol crosses the placenta and may cause fetal fluid shifts.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk or effects on the breastfed infant.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Mannitol: Increases the osmolality of plasma and glomerular filtrate, drawing water out of tissues (brain, eye) into the vascular space and producing osmotic diuresis.