سعر مانتروكسات 250مجم 120 قرص 2026

Abiraterone acetate 250 mg tablets, box of 120, by Hikma Specialized Pharmaceuticals (Egypt), for prostate cancer.

• In combination with prednisone for metastatic castration-resistant prostate cancer.Population: Adult menDailyMed (U.S. National Library of Medicine)
• In combination with prednisone for metastatic high-risk castration-sensitive prostate cancer.Population: Adult menDailyMed (U.S. National Library of Medicine)

• The US label lists no contraindications.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypertension, hypokalaemia and fluid retention from mineralocorticoid excess; control blood pressure and potassium before and during treatment and monitor at least monthly.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Adrenocortical insufficiency, especially after steroid withdrawal or under stress.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hepatotoxicity including fulminant hepatitis and fatal liver failure; measure ALT, AST and bilirubin before and during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inducers (e.g. rifampin)Reduced abiraterone exposure (by 55% with rifampin); avoid or increase dosing frequency per label.DailyMed (U.S. National Library of Medicine)

• Abiraterone acetate: Converted in vivo to abiraterone, which inhibits 17 alpha-hydroxylase/C17,20-lyase (CYP17) in testicular, adrenal and prostatic tumour tissue, lowering androgen production.