سعر Markyrene 2026

Bupivacaine injection in a 20 ml vial (amide-type local anaesthetic) from Sigma Tec/Debeiky; the listed concentration differs between sources (1% or 0.5%).

• Obstetrical paracervical block anaesthesia (fetal bradycardia and death reported); intravenous regional anaesthesia (Bier block); known hypersensitivity to bupivacaine, any amide-type local anaesthetic or other components.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Boxed warning: cardiac arrest with difficult resuscitation or death has been reported during epidural anaesthesia in obstetrical patients, mostly with the 0.75% concentration, which is not recommended for obstetrical anaesthesia.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Dose-related CNS and cardiovascular toxicity: monitor cardiovascular and respiratory vital signs and consciousness after injection; early CNS signs include restlessness, perioral numbness, metallic taste, tinnitus, dizziness, blurred vision, tremor and drowsiness.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Methemoglobinemia has been reported with local anaesthetics; patients with G6PD deficiency, congenital methemoglobinemia, cardiac or pulmonary compromise, infants under 6 months or exposure to oxidising agents are more susceptible.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Amide local anaesthetics are metabolised by the liver: consider reduced dosing and increased monitoring in moderate to severe hepatic impairment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Other local anaestheticsToxic effects of local anaesthetics are additive; monitor for neurological and cardiovascular toxicity if co-administration cannot be avoided.DailyMed (U.S. National Library of Medicine)

• Bupivacaine: Blocks generation and conduction of nerve impulses, presumably by raising the threshold for electrical excitation, slowing impulse propagation and reducing the rate of rise of the action potential (US label).