سعر ميلانوفري كريم 30 جم 0.01% / 4% / 0.05% 2024

Topical depigmenting cream (30 g tube) combining fluocinolone acetonide, hydroquinone and tretinoin, made by T3A Pharma, Egypt; Egyptian pharmacy listings give 0.01% / 4% / 0.05%.

• Short-term treatment of moderate to severe melasma of the face, together with sun avoidance and sunscreen use; not for maintenance treatmentPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most frequent in 8-week trials (N=161): erythema 41%, desquamation 38%, burning 18%, dryness 14%, pruritus 11%; also acne 5%, paresthesia 3%, telangiectasia 3%.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to the product or any of its components.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• The US product contains sodium metabisulfite, which may cause allergic-type reactions including anaphylaxis and severe asthma in susceptible people (Melanofree excipients not verified).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hydroquinone may cause exogenous ochronosis (gradual blue-black darkening of the skin); stop treatment if it occurs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Systemic absorption of the corticosteroid fluocinolone acetonide can cause reversible HPA-axis suppression, Cushing syndrome, hyperglycaemia and glucosuria.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Contains the teratogen tretinoin, which may cause embryo-fetal death, altered fetal growth, malformations and neurologic deficits; use in pregnancy only if benefit justifies risk. Trials required a negative pregnancy test and contraception.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Not known whether topical use gives detectable amounts in milk; use with caution and avoid contact between the nursing infant and the cream.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

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